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O-1871 structure.png
Clinical data
ATC code
  • none
Legal status
Legal status
  • Banned as cyclohexylphenol derivative (US, UK)
CAS Number
PubChem CID
Chemical and physical data
Formula C23H38O2
Molar mass 346.55 g/mol
3D model (JSmol)

O-1871 is a potent cannabinoid agonist which was invented by Billy R Martin and Raj K Razdan in 2002. It has a CB1 receptor affinity of 2.0nM and a CB2 receptor affinity of 0.3nM.[1] Structurally, O-1871 is a cyclohexylphenol derivative related to CP 47,497,[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivative O-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,[3] which are not cyclohexylphenol derivatives.

See also[edit]


  1. ^ Billy R Martin, Raj K Razdan. CANNABINOIDS. Patent WO 2003/091189
  2. ^ Debruyne D, Le Boisselier R. Emerging drugs of abuse: Current perspectives on synthetic cannabinoids. Substance Abuse and Rehabilitation 2015; 6: 113-129. doi:10.2147/SAR.S73586
  3. ^ Xin-Zhong Lai, Dai Lu, Alexandros Makriyannis. Novel biphenyl and biphenyl-like cannabinoids. Patent US 2004/0087590