JWH-167

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JWH-167
JWH-167 molecular structure.png
Names
IUPAC name
2-phenyl-1-(1-pentylindol-3-yl)ethanone
Other names
1-(1-pentyl-1H-indol-3-yl)-2-phenylethanone
Identifiers
864445-37-4 N
ChEMBL ChEMBL365878 YesY
ChemSpider 23256084 YesY
Jmol interactive 3D Image
PubChem 44397502
Properties
C21H23NO
Molar mass 305.42 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

JWH-167 (1-pentyl-3-(phenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75x selectivity for CB1 with a Ki of 90nM ± 17 and 159nM ± 14 at CB2. Similar to the related 2'-methoxy compound JWH-250, and the 2'-chloro compound JWH-203, JWH-167 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.[1][2]

References[edit]

  1. ^ Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223. 
  2. ^ Manera C, Tuccinardi T, Martinelli A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in medicinal chemistry 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.