AM-905 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoidagonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors. It is a potent and reasonably selective agonist for the CB1 cannabinoid receptor, with a Ki of 1.2 nM at CB1 and 5.3 nM at CB2.
^Busch-Petersen, Jakob; Hill, W. Adam; Fan, Pusheng; Khanolkar, Atmaram; Xie, Xuang-Qun; Tius, Marcus A.; Makriyannis, Alexandros (1996). "Unsaturated Side Chain β-11-Hydroxyhexahydrocannabinol Analogs". Journal of Medicinal Chemistry. 39 (19): 3790–3796. doi:10.1021/jm950934b. ISSN0022-2623.
^Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219