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Chemical compound
HU-345![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b3/HU-345_Structure.svg/220px-HU-345_Structure.svg.png) |
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6,6,9-Trimethyl-3-pentyl-1H-benzo[c]chromene-1,4(6H)-dione
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PubChem CID | |
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ChemSpider | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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Formula | C21H24O3 |
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Molar mass | 324.420 g·mol−1 |
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3D model (JSmol) | |
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O=C2\C(=C/C(=O)C=3c1c(ccc(c1)C)C(OC2=3)(C)C)CCCCC
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InChI=1S/C21H24O3/c1-5-6-7-8-14-12-17(22)18-15-11-13(2)9-10-16(15)21(3,4)24-20(18)19(14)23/h9-12H,5-8H2,1-4H3 YKey:UFDYTRQMIXJHTH-UHFFFAOYSA-N Y
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HU-345 (cannabinol quinone) is a drug that is able to inhibit aortic ring angiogenesis more potently than its parent compound cannabinol (CBN).[1][2] It exhibits no psychoactive effects on the body.
HU-345 can be derived through the oxidative degradation of CBN.[3]
- ^ Kogan NM, Blázquez C, Alvarez L, Gallily R, Schlesinger M, Guzmán M, Mechoulam R (July 2006). "A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells". Molecular Pharmacology. 70 (1): 51–59. doi:10.1124/mol.105.021089. PMID 16571653. S2CID 4830577.
- ^ US patent 0092584, Mechoulam R, Kogan NM, Rabinowitz R, Schlesinger M, "Therapeutic Use of Quinonoid Derivatives of Cannabinoids", granted 2011-04-21
- ^ Kogan NM, Peters M, Mechoulam R (March 2021). "Cannabinoid Quinones-A Review and Novel Observations". Molecules. 26 (6): 1761. doi:10.3390/molecules26061761. PMC 8003933. PMID 33801057.
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Phytocannabinoids (comparison) | Cannabibutols | |
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Cannabichromenes | |
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Cannabicyclols | |
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Cannabidiols | |
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Cannabielsoins | |
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Cannabigerols | |
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Cannabiphorols | |
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Cannabinols | |
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Cannabitriols | |
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Cannabivarins | |
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Delta-8-tetrahydrocannabinols | |
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Delta-9-tetrahydrocannabinols | |
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Delta-10-Tetrahydrocannabinols | |
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Miscellaneous cannabinoids | |
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Active metabolites | |
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Endocannabinoids | |
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Synthetic cannabinoid receptor agonists / neocannabinoids | Classical cannabinoids (dibenzopyrans) | |
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Non-classical cannabinoids | |
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Adamantoylindoles | |
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Benzimidazoles | |
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Benzoylindoles | |
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Cyclohexylphenols | |
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Phenylacetylindoles | |
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Tetramethylcyclo- propanoylindazoles | |
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Others | |
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Allosteric CBRTooltip Cannabinoid receptor ligands | |
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