Tedalinab

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Tedalinab
Tedalinab structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C19H21F2N3O
Molar mass 345.385 g/mol
3D model (Jmol)

Tedalinab (GRC-10693) is a drug developed by Glenmark Pharmaceuticals for the treatment of osteoarthritis and neuropathic pain, which acts as a potent and selective cannabinoid CB2 receptor agonist. It has a very high selectivity of 4700x for CB2 over the related CB1 receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and antiinflammatory actions in early clinical trials.[1] A large number of related compounds are known, most of which also show high CB2 selectivity.[2]

See also[edit]

References[edit]

  1. ^ Glenmark’s Molecule for Neuropathic Pain, Osteoarthritis - GRC 10693, Successfully Completes Phase I Trials. April 13, 2009.
  2. ^ Glenmark Pharmaceuticals. NOVEL CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION, Filed June 1st, 2006. WO 2006/129178.