Tedalinab

Tedalinab

Identifiers
IUPAC name (4S,7R)-1-(2,4-difluorophenyl)-N-(1,1-dimethylethyl)-4,5,6,7-tetrahydro-4,7-methano-1H-indazole-3-carboxamide
CAS Number	916591-01-0
PubChem CID	24872953
ChemSpider	29340966
UNII	5R7X34Y6Q1
Chemical and physical data
Formula	C19H21F2N3O
Molar mass	345.394 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)NC(=O)C1=NN(C2=C1[C@@H]3CC[C@H]2C3)C4=C(C=C(C=C4)F)F
InChI InChI=1S/C19H21F2N3O/c1-19(2,3)22-18(25)16-15-10-4-5-11(8-10)17(15)24(23-16)14-7-6-12(20)9-13(14)21/h6-7,9-11H,4-5,8H2,1-3H3,(H,22,25)/t10-,11+/m0/s1 Key:NTPZXHMTJGOMCJ-WDEREUQCSA-N

Tedalinab (GRC-10693) is a drug developed by Glenmark Pharmaceuticals for the treatment of osteoarthritis and neuropathic pain, which acts as a potent and selective cannabinoid CB₂ receptor agonist. It has a very high selectivity of 4700x for CB₂ over the related CB₁ receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and antiinflammatory actions in early clinical trials. Many related compounds are known, most of which also show high CB₂ selectivity.

See also

• CBS-0550
• Olorinab
• SER-601