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JWH-018

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JWH-018
Legal status
Legal status
Identifiers
  • Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.163.574 Edit this at Wikidata
Chemical and physical data
FormulaC24H23NO
Molar mass341.45 g/mol g·mol−1
Solubility in waterhydrophobic, n/a mg/mL (20 °C)

JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with some selectivity for CB2.[1][2][3] It produces effects in animals very similar to those of THC itself, but with a longer duration of action.

History

On December 15th 2008, it was reported by the German pharmaceutical company THC Pharm, that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense, in a number of countries around the world since 2002. [4][5][6]


Several countries have placed legal restrictions on the compound.

Austria

The Austrian Ministry of Health announced on 18th December 2008 that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance which affects the functions of the body, and the legality of JWH-018 is under review.

Germany

JWH-018 is illegal in Germany since 22nd of January 2009.[7]

Latvia

JWH-018 is illegal in Latvia since 28 November 2009.[8]

Lithuania

JWH-018 is illegal in Lithuania since 5th of June 2009.[9]

Sweden

JWH-018 is illegal in Sweden since 30th of July 2009. The bill was accepted on 30th July 2009 and was in effect on 15th September 2009.[10]

Estonia

JWH-018 is illegal in Estonia since 24th of July 2009

Russia

JWH-018 is illegal in Russia since 15th of January 2010.

Belarus

JWH-018 is illegal in Belarus since 1st of January 2010.

UK

JWH-018 is illegal in the UK since 23rd of December 2009.[11]

United States

JWH-018 is currently not federally controlled in the U.S., but the Drug Enforcement Administration labeled it a "drug and chemical of concern" in 2009. Lawmakers in the state of Kansas are currently considering bills that would ban JWH-018. [12]

See also

References

  1. ^ Aung, M. M. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–140. doi:10.1016/S0376-8716(99)00152-0. {{cite journal}}: Cite has empty unknown parameter: |month= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  2. ^ US patent 6900236, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2005-05-31 
  3. ^ US patent 7241799, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2007-07-10 
  4. ^ Gefährlicher Kick mit Spice (German)
  5. ^ Erstmals Bestandteile der Modedroge „Spice“ nachgewiesen (German)
  6. ^ Spice enthält chemischen Wirkstoff (German)
  7. ^ BGBl I Nr. 3 vom 21.01.2009, 22. BtMÄndV vom 19. Januar 2009, S. 49–50.
  8. ^ [1]
  9. ^ http://www3.lrs.lt/pls/inter3/dokpaieska.showdoc_l?p_id=345197
  10. ^ [2](Swedish)
  11. ^ http://business.timesonline.co.uk/tol/business/law/article6965663.ece
  12. ^ http://www.phoenixnewtimes.com/2010-02-04/news/up-in-smoke-valley-smokers-buy-steal-and-inhale-jwh-018-to-get-high-and-they-say-it-s-working/
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