JWH-200
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| Formula | C25H24N2O2 |
| Molar mass | 384.469 g/mol g·mol−1 |
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JWH-200 (WIN 55,225)[1] is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[2] but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro,[3] around 3 times that of THC but with less sedative effect,[4] most likely reflecting favourable pharmacokinetic characteristics. It was discovered by, and named after, Dr. John W. Huffman.
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9313864, please use {{cite journal}} with
|pmid=9313864instead. - ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
- ^ Bell MR, D'Ambra TE, Kumar V, et al. (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
- ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057
External links
- [www.titaniumwf.com Manufacture and Sale]
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This Drug is legal and not controlled in Canada (up to date to may 14,2010)[1]