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JWH-359

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JWH-359
Identifiers
  • (6aR,10aR)- 1-methoxy- 6,6,9-trimethyl- 3-[(2R)-1,1,2-trimethylbutyl]- 6a,7,10,10a-tetrahydrobenzo[c]chromene
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H36O2
Molar mass356.540 g/mol g·mol−1
3D model (JSmol)
  • COc2cc(C(C)(C)C(C)CC)cc3c2C1CC(C)=CCC1C(C)(C)O3

JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB2 receptor agonist, with a Ki of 13.0nM and selectivity of around 220x for CB2 over CB1 receptors. It is related to other dibenzopyran CB2 agonists such as JWH-133 and L-759,656 but with a chiral side chain which has made it useful in mapping the shape of the CB2 binding site.[1][2]. It was discovered by, and named after, Dr. John W. Huffman.

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References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16165365, please use {{cite journal}} with |pmid=16165365 instead.
  2. ^ http://www.ncbi.nlm.nih.gov/pubmed/18289088
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