Paleolithic diet

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This article is about a modern nutritional approach. For information on the dietary practices of Paleolithic humans, see Paleolithic § Diet and nutrition.
Paleolithic-style dish: seafood stew

The paleolithic diet (abbreviated paleo diet or paleodiet), also popularly referred to as the caveman diet, Stone Age diet and hunter-gatherer diet, is a modern nutritional plan based on the presumed ancient diet of wild plants and animals that various hominid species habitually consumed during the Paleolithic era—a period of about 2.5 million years duration that ended around 10,000 years ago with the development of agriculture. In common usage, such terms as the "Paleolithic diet" also refer to the actual ancestral human diet.[1][2]

Centered on commonly available modern foods, the "contemporary" Paleolithic diet consists mainly of fish, grass-fed pasture raised meats, vegetables, fruit, fungi, roots, and nuts, and excludes grains, legumes, dairy products, salt, refined sugar, and processed oils.[1][3][4]

First popularized in the mid-1970s by gastroenterologist Walter L. Voegtlin,[5][6] this nutritional concept has been promoted and adapted by a number of authors and researchers in several books and academic journals.[7] A common theme in evolutionary medicine,[8][9] Paleolithic nutrition is based on the premise that modern humans are genetically adapted to the diet of their Paleolithic ancestors and that human genetics have scarcely changed since the dawn of agriculture, and therefore that an ideal diet for human health and well-being is one that resembles this ancestral diet.[4][10] Proponents of this diet argue that modern human populations subsisting on traditional diets allegedly similar to those of Paleolithic hunter-gatherers are largely free of diseases of affluence,[11][12] and that two small prospective studies of the Paleolithic diet in humans have shown some positive health outcomes.[13][14] Supporters point to several potentially therapeutic nutritional characteristics of allegedly preagricultural diets.[10][15]

This dietary approach is a controversial topic amongst dietitians[16][17] and anthropologists,[7][18] and an article on the National Health Service of the United Kingdom Choices website suggests that it may be a fad diet.[19] Critics have argued that if hunter-gatherer societies failed to suffer from "diseases of civilization", this was due to reduced calories in their diet, or a variety of other factors, rather than because of some special diet composition.[20] Some researchers have taken issue with the accuracy of the diet's underlying evolutionary logic.[20][21][22]

Also disputed are some dietary recommendations and restrictions on the grounds that they provide no health benefits or pose health risks[20][21] and are not likely to accurately reflect the features of ancient Paleolithic diets.[22][23]

A 2011 ranking by U.S. News & World Report, involving a panel of 22 experts, ranked the Paleo diet lowest of the 20 diets evaluated based on factors including health, weight-loss and ease of following.[24] These results were repeated in the 2012 survey, where the diet placed 24th out of 24, stating that their experts "took issue with the diet on every measure".[24] However, one expert involved in the ranking stated that a "true Paleo diet might be a great option: very lean, pure meats, lots of wild plants. The modern approximations… are far from it."[24] He quickly added that "duplicating such a regimen in modern times would be difficult."[24]

The ranking assumed a modernized offshoot to the paleo diet in which low-carb is emphasized, this diet specifically containing only 23% carbohydrates.[25] Higher carbohydrate versions of the paleo diet, which allow for significant consumption of root vegetables,[26] were not a part of this ranking.[24] Loren Cordain, a proponent of a low-carbohydrate Paleolithic diet, responded to the U.S. News ranking, stating that their "conclusions are erroneous and misleading" and pointing out that "five studies, four since 2007, have experimentally tested contemporary versions of ancestral human diets and have found them to be superior to Mediterranean diets, diabetic diets and typical western diets in regards to weight loss, cardiovascular disease risk factors and risk factors for type 2 diabetes."[27] The editors of U.S. News replied that their ranking included a review of all five studies which found that all of them were small and/or of short duration.

History

Gastroenterologist Walter L. Voegtlin was one of the first to suggest that following a diet similar to that of the Paleolithic era would improve a person's health.[6] In 1975, he self-published The Stone Age Diet: Based on in-depth Studies of Human Ecology and the Diet of Man,[5] in which he argued that humans are carnivorous animals and that the ancestral Paleolithic diet was that of a carnivore — chiefly fats and protein, with only small amounts of carbohydrates.[28][29] His dietary prescriptions were based on his own medical treatments of various digestive problems, namely colitis, Crohn's disease, irritable bowel syndrome and indigestion.[30][31]

In 1985, S. Boyd Eaton and Melvin Konner, both of Emory University, published a key paper on Paleolithic nutrition in the New England Journal of Medicine,[32] which caused the concept to gain mainstream medical attention.[33] Three years later, S. Boyd Eaton, Marjorie Shostak and Melvin Konner published a book about this nutritional approach,[34] which was based on achieving the same proportions of nutrients (fat, protein, and carbohydrates, as well as vitamins and minerals) as were present in the diets of late Paleolithic people, not on excluding foods that were not available before the development of agriculture. As such, this nutritional approach included skimmed milk, whole-grain bread, brown rice, and potatoes prepared without fat, on the premise that such foods supported a diet with the same macronutrient composition as the Paleolithic diet.[28][35][36] In 1989, these authors published a second book on Paleolithic nutrition.[37][38]

Starting in 1989, Swedish medical doctor and scientist Staffan Lindeberg, now associate professor at Lund University, Sweden, led scientific surveys of the non-westernized population on Kitava, one of the Trobriand Islands of Papua New Guinea. These surveys, collectively referred to as the Kitava Study, found that this population apparently did not suffer from stroke, ischemic heart disease, diabetes, obesity or hypertension. Starting with the first publication in 1993,[39] the Kitava Study has subsequently generated a number of scientific publications on the relationship between diet and western disease.[40] In 2003, Lindeberg published a Swedish language medical textbook on the subject.[41] In 2010, this book was wholly revised, updated and published for the first time in English. The 2010 book[42] is geared towards both professionals and interested laypeople alike, cites more than 2000 references, and provides a comprehensive resource for the scientific foundation for the Paleolithic diet and the relationship between what humans eat and western diseases.

Since the end of the 1990s, a number of medical doctors and nutritionists[43][44][45] have advocated a return to a so-called Paleolithic (preagricultural) diet.[7] Proponents of this nutritional approach have published books[46][47][48] and created websites [49] [50][51] [52] to promote their dietary prescriptions.[53][54][55][56][57] They have synthesized diets from modern foods that emulate nutritional characteristics of the ancient Paleolithic diet, some of which allow specific foods that would have been unavailable to pre-agricultural peoples, such as some animal products (i.e. dairy), processed oils, and beverages.[46][58][59]

Practices

Raw Paleolithic-style dish: sashimi (raw fish) dinner set

The Paleolithic diet is a modern dietary regimen that seeks to mimic the diet of preagricultural hunter-gatherers, one that corresponds to what was available in any of the ecological niches of Paleolithic humans.[1][4] Based upon commonly available modern foods, it includes cultivated plants and domesticated animal meat as an alternative to the wild sources of the original preagricultural diet.[1][3][60] The ancestral human diet is inferred from historical and ethnographic studies of modern-day hunter-gatherers as well as archaeological finds, anthropological evidence and application of optimal foraging theory.[10][61][62][63]

The Paleolithic diet consists of foods that can be hunted and fished, such as meat, offal and seafood, and can be gathered, such as eggs, insects, fruit, nuts, seeds, vegetables, mushrooms, herbs and spices.[1][3] Some sources advise eating only lean cuts of meat, free of food additives, preferably wild game meats and grass-fed beef since they contain higher levels of omega-3 fats compared with grain-produced domestic meats.[1][3][60][64] Food groups that advocates claim were rarely or never consumed by humans before the Neolithic (agricultural) revolution are excluded from the diet, mainly grains, legumes (e.g. beans and peanuts), dairy products, salt, refined sugar and processed oils,[1][3] although some advocates consider the use of oils with low omega-6/omega-3 ratios, such as olive oil and canola oil, to be healthy and advisable.[60]

Paleolithic-style dish: roast pork with cooked and raw vegetables and fruit

More moderately, Kurt G. Harris recommends avoiding fructose, linoleic acid, and gluten grains as the primary Neolithic agents responsible for modern diseases, and "the rest is just tinkering around the edges." [65][66]

On the Paleolithic diet, practitioners are permitted to drink mainly water, and some advocates recommend tea as a healthy drink,[60] but alcoholic and fermented beverages are restricted from the diet.[3][60] Furthermore, eating a wide variety of plant foods is recommended to avoid high intakes of potentially harmful bioactive substances, such as goitrogens, which are present in some roots, vegetables and seeds.[1][61][67] Unlike raw food diets, all foods may be cooked, without restrictions.[1][68] However, raw Paleolithic dieters exist who believe that humans have not adapted to cooked foods, and so they eat only foods which are both raw and Paleolithic.[69][70]

According to certain proponents of the Paleolithic diet, practitioners should derive about 56–65% of their food energy from animal foods and 36–45% from plant foods. They recommend a diet high in protein (19–35% energy) and relatively low in carbohydrates (22–40% energy), with a fat intake (28–58% energy) similar to or higher than that found in Western diets.[60][71][72] Furthermore, some proponents exclude from the diet foods which exhibit high glycemic indices, such as potatoes.[3] Staffan Lindeberg advocates a Paleolithic diet, but does not recommend any particular proportions of plants versus meat or macronutrient ratios.[1][61]

According to Lindeberg, calcium supplementation may be considered when the intake of green leafy vegetables and other dietary sources of calcium is limited.[1]

Rationale and evolutionary assumptions

According to S. Boyd Eaton, "we are the heirs of inherited characteristics accrued over millions of years; the vast majority of our biochemistry and physiology are tuned to life conditions that existed before the advent of agriculture some 10,000 years ago. Genetically our bodies are virtually the same as they were at the end of the Paleolithic era some 20,000 years ago."[73]

Paleolithic nutrition has its roots in evolutionary biology and is a common theme in evolutionary medicine.[8][9][74] The reasoning underlying this nutritional approach is that natural selection had sufficient time to genetically adapt the metabolism and physiology of Paleolithic humans to the varying dietary conditions of that era. But in the 10,000 years since the invention of agriculture and its consequent major change in the human diet, natural selection has had too little time to make the optimal genetic adaptations to the new diet.[1] Physiological and metabolic maladaptations result from the suboptimal genetic adaptations to the contemporary human diet, which in turn contribute to many of the so-called diseases of civilization.[4]

More than 70% of the total daily energy consumed by all people in the United States comes from foods such as dairy products, cereals, refined sugars, refined vegetable oils and alcohol, that advocates of the Paleolithic diet assert contributed little or none of the energy in the typical preagricultural hominin diet.[10] Proponents of this diet argue that excessive consumption of these novel Neolithic and Industrial era foods is responsible for the current epidemic levels of obesity, cardiovascular disease, high blood pressure, type 2 diabetes, osteoporosis and cancer in the US and other contemporary Western populations.[10]

Physical activity

The evolutionary rationale has also been applied by researchers into the paleolithic lifestyle to argue for high levels of physical activity in addition to dietary practices. It has been proposed that human genes "evolved with the expectation of requiring a certain threshold of physical activity" and that sedentary lifestyle results in abnormal gene expression.[75][76] Compared to ancestral humans, modern humans often have substantially less lean muscle, which is a risk factor for insulin resistance.[77] Human metabolic processes were evolved in the presence of physical activity-rest cycles, which regularly depleted skeletal muscles of their glycogen stores.[78] S. Boyd Eaton estimated that ancestral humans spent one-third of their caloric intake on physical activity (1000 kcal/day out of the total caloric intake of 3000 kcal/day), [79] and that the paleolithic lifestyle was well approximated by the WHO recommendation of the physical activity level of 1.75, or 60 minutes/day of moderate-intensity exercise.[80] L. Cordain estimated that the optimal level of physical activity is on the order of 90 kcal/kg/week (900 kcal/day for a 70 kg human.)[76]

Opposing views

The evolutionary assumptions underlying the Paleolithic diet have been disputed.[18][21][22][35] According to Alexander Ströhle, Maike Wolters and Andreas Hahn, with the Department of Food Science at the University of Hanover, the statement that the human genome evolved during the Pleistocene (a period from 1,808,000 to 11,550 years ago) rests on an inadequate, but popular gene-centered view of evolution.[22] They rely on Gray (2001)[81] to argue that evolution of organisms cannot be reduced to the genetic level with reference to mutation and that there is no one-to-one relationship between genotype and phenotype.[22]

They further question the notion that 10,000 years is an insufficient period of time to ensure an adequate adaptation to agrarian diets.[22] For example, alleles conferring lactose tolerance increased to high frequencies in Europe just a few thousand years after animal husbandry was invented, and recent increases in the number of copies of the gene for salivary amylase, which digests starch, appear to be related to agriculture.[citation needed] Referring to Wilson (1994),[82] Ströhle et al. argue that "the number of generations that a species existed in the old environment was irrelevant, and that the response to the change of the environment of a species would depend on the heritability of the traits, the intensity of selection and the number of generations that selection acts."[83] They state that if the diet of Neolithic agriculturalists had been in discordance with their physiology, then this would have created a selection pressure for evolutionary change and modern humans, such as Europeans, whose ancestors have subsisted on agrarian diets for 400–500 generations should be somehow adequately adapted to it. In response to this argument, Wolfgang Kopp states that "we have to take into account that death from atherosclerosis and cardiovascular disease (CVD) occurs later during life, as a rule after the reproduction phase. Even a high mortality from CVD after the reproduction phase will create little selection pressure. Thus, it seems that a diet can be functional (it keeps us going) and dysfunctional (it causes health problems) at the same time."[83] Moreover, S. Boyd Eaton and colleagues have indicated that "comparative genetic data provide compelling evidence against the contention that long exposure to agricultural and industrial circumstances has distanced us, genetically, from our Stone Age ancestors"[12] however they mention exceptions such as increased lactose and gluten tolerance, which improve ability to digest dairy and grains, while other studies indicate that human adaptive evolution has accelerated since the Paleolithic.[84]

Referencing Mahner et al. (2001)[85] and Ströhle et al. (2006),[86] Ströhle et al. state that "whatever is the fact, to think that a dietary factor is valuable (functional) to the organism only when there was ‘genetical adaptation’ and hence a new dietary factor is dysfunctional per se because there was no evolutionary adaptation to it, such a panselectionist misreading of biological evolution seems to be inspired by a naive adaptationistic view of life."[22]

Katharine Milton, a professor of physical anthropology at the University of California, Berkeley, has also disputed the evolutionary logic upon which the Paleolithic diet is based. She questions the premise that the metabolism of modern humans must be genetically adapted to the dietary conditions of the Paleolithic.[18] Relying on several of her previous publications,[87][88][89][90] Milton states that "there is little evidence to suggest that human nutritional requirements or human digestive physiology were significantly affected by such diets at any point in human evolution."[18]

Evidence suggests the diet of Stone Age humans did include, in some form, the refined starches and grains that are excluded from the Paleolithic diet. There is evidence that Paleolithic societies were processing cereals for food use at least as early as 23,000[91][92] or 30,000 years ago,[93] and possibly as early as 105,000[94] or 200,000 years ago.[95]

Plant-to-animal ratio

The specific plant to animal food ratio in the Paleolithic diet is also a matter of some dispute. The mean diet among modern hunter-gatherer societies is estimated to consist of 64–68% of animal calories and 32–36% of plant calories,[72][96] with animal calories further divided between fished and hunted animals in varying proportions (most typically, with hunted animal food comprising 26–35% of the overall diet). As part of the Man the Hunter paradigm, this ratio was used as the basis of the earliest forms of the Paleolithic diet by Voegtlin, Eaton and others. To this day, many advocates of the Paleolithic diet consider high percentage of animal flesh to be one of the key features of the diet.

However, great disparities do exist, even between different modern hunter-gatherer societies. The animal-derived calorie percentage ranges from 25% in the Gwi people of southern Africa, to 99% in Alaskan Nunamiut.[97] The animal-derived percentage value is skewed upwards by polar hunter-gatherer societies, who have no choice but to eat animal food because of the inaccessibility of plant foods. Since those environments were only populated relatively recently (for example, Paleo-Indian ancestors of Nunamiut are thought to have arrived in Alaska no earlier than 30,000 years ago), such diets represent recent adaptations rather than conditions that shaped human evolution during much of the Paleolithic. More generally, hunting and fishing tend to provide a higher percentage of energy in forager societies living at higher latitudes. Excluding cold-climate and equestrian foragers results in a diet structure of 52% plant calories, 26% hunting calories, and 22% fishing calories.[96] Furthermore, those numbers may still not be representative of a typical Stone Age diet, since fishing did not become common in many parts of the world until the Upper Paleolithic period 35-40 thousand years ago,[98] and early humans' hunting abilities were relatively limited [dubious – discuss], compared to modern hunter-gatherers, as well (the oldest incontrovertible evidence for the existence of bows only dates to about 8000 BCE,[99] and nets and traps were invented 22,000 to 29,000 years ago).

Another view is that, up until the Upper Paleolithic, humans were frugivores (fruit eaters), who supplemented their meals with carrion, eggs, and small prey such as baby birds and mussels, and, only on rare occasions, managed to kill and consume big game such as antelopes.[100] Jared Diamond described a hunt by a tribe in New Guinea, in which the day's total bag was two baby birds ("weighing about one-third of an ounce each"), a few frogs, and a lot of mushrooms. Although the men of the tribe frequently boasted of the large animals they had killed, when pressed for details, they admitted that large animals were killed only a few times in a hunter's career. Unlike Stone Age humans, these people did have bows and arrows, and their stone tools were far more advanced than the stone tools found on prehistoric sites. According to Diamond, it is unlikely that prehistoric hunters could have enjoyed a much higher success rate than present day hunter-gatherer tribes.[101][102]

This view is supported by the studies of higher apes, particularly chimpanzees. Chimpanzees are closest to humans genetically, sharing more than 98% of their DNA code with humans, and their digestive tract is functionally very similar to that of humans [citation needed]. Chimpanzees are primarily frugivores, but they could and would consume and digest animal flesh, given the opportunity. However, their actual diet in the wild is about 95% plant-based, with the remaining 5% filled with insects, eggs, and baby animals.[103][104] Some comparative studies of human and higher primate digestive tracts do suggest that humans have evolved to obtain greater amounts of calories from high-quality sources such as animal foods, allowing them to shrink the size of the gastrointestinal tract, relative to body mass, and to increase the brain mass instead.[89][105]

A difficulty with this point of view is that humans are established to conditionally require certain long-chain polyunsaturated fatty acids (LC-PUFAs), such as AA and DHA, from the diet.[106] Human LC-PUFA requirements are much greater than chimpanzees' because of humans' larger brain mass, and humans' abilities to synthesize them from other nutrients are poor, suggesting readily available external sources.[107] Pregnant and lactating females require 100 mg of DHA per day.[108] But LC-PUFAs are nonexistent in plants, and DHA is also almost nonexistent in most tissues of warm-climate animals.

The source of DHA in the modern human diet is fish and fatty organs of animal like brains, eyes and viscera. Despite the general shortage of evidence for extensive fishing, thought to require relatively sophisticated tools which have become available only in the last 30–50 thousand years, it has been argued that exploitation of coastal fauna somehow provided hominids with abundant LC-PUFAs.[107] Alternatively, it has been proposed that early hominids frequently scavenged predators' kills and consumed parts which were left untouched by predators, most commonly the brain, which is very high in AA and DHA.[108] Just 100 g of scavenged African ruminant brain matter provide more DHA than is consumed by a typical modern U.S. adult in the course of a week.[108][109] Other authors suggested that human ability to convert alpha-Linolenic acid into DHA, while poor, is, nevertheless, adequate to prevent DHA deficiency in a plant-based diet.[110]

Nutritional factors and health effects

Fruits and vegetables, rich in vitamins, potassium and fiber, represent an important feature of hunter-gatherer diets.[10]

Since the end of the Paleolithic period, several foods that humans rarely or never consumed during previous stages of their evolution have been introduced as staples in their diet.[10] With the advent of agriculture and the beginning of animal domestication roughly 10,000 years ago, during the Neolithic Revolution, humans started consuming large amounts of dairy products, beans, cereals, alcohol and salt.[10] In the late 18th and early 19th centuries, the Industrial revolution led to the large scale development of mechanized food processing techniques and intensive livestock farming methods, that enabled the production of refined cereals, refined sugars and refined vegetable oils, as well as fattier domestic meats, which have become major components of Western diets.[10]

Such food staples have fundamentally altered several key nutritional characteristics of the human diet since the Paleolithic era, including glycemic load, fatty acid composition, macronutrient composition, micronutrient density, acid-base balance, sodium-potassium ratio, and fiber content.[10]

These dietary compositional changes have been theorized as risk factors in the pathogenesis of many of the so-called "diseases of civilization" and other chronic illnesses that are widely prevalent in Western societies,[4][10][111][112][113][114] including obesity,[115][116][117] cardiovascular disease,[118][119][120] high blood pressure,[121] type 2 diabetes,[122][123] osteoporosis,[124][125] autoimmune diseases,[126] colorectal cancer,[127][128][129] myopia,[130] acne,[131][132][133][134] depression,[135] and diseases related to vitamin and mineral deficiencies.[126][136][137][138]

Macronutrient composition

Protein and carbohydrates

"The increased contribution of carbohydrate from grains to the human diet following the agricultural revolution has effectively diluted the protein content of the human diet."[139] In modern hunter-gatherer diets, dietary protein is characteristically elevated (19–35% of energy) at the expense of carbohydrate (22–40% of energy).[71][72][140] High-protein diets may have a cardiovascular protective effect and may represent an effective weight loss strategy for the overweight or obese.[10] Furthermore, carbohydrate restriction may help prevent obesity and type 2 diabetes,[141][142] as well as atherosclerosis.[120] Carbohydrate deprivation to the point of ketosis has been argued both to have negative[143] and positive effects on health.[144][145]

Nuts such as walnuts (pictured above) are rich sources of protein and micronutrients.

The notion that preagricultural hunter-gatherers would have typically consumed a diet relatively low in carbohydrate and high in protein has been questioned.[146] Critics argue that there is insufficient data to identify the relative proportions of plant and animal foods consumed on average by Paleolithic humans in general,[7][18][23][86] and they stress the rich variety of ancient and modern hunter-gatherer diets.[18][21][22] Furthermore, preagricultural hunter-gatherers may have generally consumed large quantities of carbohydrates in the form of carbohydrate-rich tubers (plant underground storage organs).[17][21][22] According to Staffan Lindeberg, an advocate of the Paleolithic diet, a plant-based diet rich in carbohydrates is consistent with the human evolutionary past.[1][4]

It has also been argued that relative freedom from degenerative diseases was, and still is, characteristic of all hunter-gatherer societies irrespective of the macronutrient characteristics of their diets.[20][147][148] Marion Nestle, a professor in the Department of Nutrition and Food Studies at New York University, judging from research relating nutritional factors to chronic disease risks and to observations of exceptionally low chronic disease rates among people eating vegetarian, Mediterranean and Asian diets, has suggested that plant-based diets may be most associated with health and longevity.[16][23]

Fatty acids

Hunter-gatherer diets have been argued to maintain relatively high levels of monounsaturated and polyunsaturated fats, moderate levels of saturated fats (10–15% of total food energy[149]) as well as a low omega-6:omega-3 fatty acid ratio.[10][72][150] Cows fed a grass-based diet produce significant amounts of omega-3 fatty acids compared to grain-fed animals, while minimizing trans fats and saturated fats.[151] The diet does include a significant amount of cholesterol due to the inclusion of lean meat.[152] These nutritional factors may serve to inhibit the development of cardiovascular disease.[10] This high ratio of polyunsaturated to saturated fats has been challenged. While a low saturated fat intake was argued for[72] it has been argued that hunter-gatherers would selectively hunt fatter animals and utilise the fattiest parts of the animals (such as bone marrow).[153]

Energy density

The Paleolithic diet has lower energy density than the typical diet consumed by modern humans.[154] This is especially true in primarily plant-based/vegetarian versions of the diet, but it still holds if substantial amounts of lean meat are included in calculations. For example, most fruits and berries contain 0.4 to 0.8 calories per gram, vegetables can be even lower than that (cucumbers contain only 0.16 calories per gram).[155] Lean game meat, such as cooked wild rabbit, is more energy-dense (up to 1.7 calories per gram), but it does not constitute the bulk of the diet by mass/volume at the recommended plant/animal ratios, and it does not reach the densities of many processed foods commonly consumed by modern humans: most McDonalds sandwiches such as the Big Mac average 2.4 to 2.8 calories/gram,[156] and sweets such as cookies and chocolate bars commonly exceed 4 calories/gram.

There is substantial evidence that people consuming high energy-density diets are prone to overeating and they are at a greater risk of weight gain. Conversely, low caloric density diets tend to provide a greater satiety feeling at the same energy intake, and they have been shown effective at achieving weight loss in overweight individuals without explicit caloric restrictions.[157][158][159]

Even some authors who may otherwise appear to be critical of the concept of Paleolithic diet have argued that high energy density of modern diets, as compared to ancestral/primate diets, contributes to the rate of diseases of affluence in the industrial world.[90]

Micronutrient density

Fish and seafood, such as salmon (pictured above), are significant sources of essential micronutrients.

Fruits, vegetables, meat and organ meats, and seafood, which are staples of the hunter-gatherer diet, are more micronutrient-dense than refined sugars, grains, vegetable oils, and dairy products in relation to digestible energy. Consequently, the vitamin and mineral content of the diet is very high compared with a standard diet, in many cases a multiple of the RDA.[3] Fish and seafood represent a particularly rich source of omega-3 fatty acids and other micronutrients, such as iodine, iron, zinc, copper, and selenium, that are crucial for proper brain function and development.[136] Terrestrial animal foods, such as muscle, brain, bone marrow, thyroid gland, and other organs, also represent a primary source of these nutrients.[67] Calcium-poor grains and legumes are excluded from the diet.[160][161][162] Two notable exceptions are calcium (see below) and vitamin D, both of which may be present in the diet in inadequate quantities. Modern humans require much more vitamin D than hunter-gatherers, because they do not get the same amount of exposure to sun. This need is commonly satisfied in developed countries by artificially fortifying dairy products with the vitamin. To avoid deficiency, a modern human on a hunter-gatherer diet would have to take artificial supplements of the vitamin, ensure adequate intake of some fatty fish,[163] or increase the amount of exposure to sunlight (it has been estimated that 30 minutes of exposure to mid-day sun twice a week is adequate for most people).[164]

Fiber content and glycemic load

Despite its relatively low carbohydrate content, the Paleolithic diet involves a substantial increase in consumption of fruit and vegetables, compared to the Western diet, potentially as high as 1.65 to 1.9 kg/day.[3][165] This leads to fiber intake which is significantly larger than either current or recommended values.[3] Hunter-gatherer diets, which rely on uncultivated, heavily fibrous fruit and vegetables, contain even more. Fiber intake in preagricultural diets is thought to have exceeded 100 g/day.[73] This is dramatically higher than the actual current U.S. intake of 15 g/day.[73]

Fiber-rich root vegetables, such as beets, rutabagas, carrots, celeriac and turnips, maintain nutrient properties (low glycemic and insulin responses) characteristic of traditional hunter-gatherer plant foods.[3]

Unrefined wild plant foods like those available to contemporary hunter-gatherers typically exhibit low glycemic indices.[166] Moreover, dairy products, such as milk, have low glycemic indices, but are highly insulinotropic, with an insulin index similar to that of white bread.[167][168] However, in fermented milk products, such as yogurt, the presence of organic acids may counteract the insulinotropic effect of milk in mixed meals.[169] These dietary characteristics may lower risk of diabetes, obesity and other related syndrome X diseases by placing less stress on the pancreas to produce insulin, and preventing insulin insensitivity.[170]

Sodium-potassium ratio

It has been estimated that people in the Paleolithic era consumed 11,000 mg of potassium and 700 mg of sodium daily.[32] The modern Paleolithic diet includes neither processed foods (which often contains salt as a preservative) nor added salt as a condiment. The sodium intake of the diet (~726 mg) is lower than average U.S. values (3,271 mg) or recommended values (1,500 mg). Further, since potassium-rich fruits and vegetables compose ~30% of the daily energy, the potassium content (~9,062 mg) is nearly 3.5 times greater than average values (2,620 mg) in the U.S. diet.[3]

The dominance of sodium over potassium in the U.S. diet adversely affects cardiovascular function and contributes to hypertension and stroke:[125][171] the Paleolithic diet inverts this ratio.

Calcium and acid-base balance

Diets containing high amounts of salt or cereals and other foods that induce and sustain increased acidity of body fluid may contribute to the development of osteoporosis and renal stones, loss of muscle mass, and age-related renal insufficiency due to the body's use of calcium to buffer pH.[citation needed] The paleo diet may not contain the high levels of calcium recommended in the U.S. to prevent these effects.[152] However, because of the absence of acid yielding cereals and energy-dense, nutrient-poor foods in the hunter-gatherer diet—foods that displace base-yielding fruits and vegetables—the diet produces a net base load on the body, as opposed to a net acid load, which may reduce calcium excretion.[124][172] [failed verification]

Bioactive substances and antinutrients

Furthermore, cereal grains, legumes and milk contain bioactive substances, such as gluten and casein, which have been implicated in the development of various health problems.[4] Consumption of gluten, a component of certain grains, such as wheat, rye and barley, is known to have adverse health effects in individuals suffering from a range of gluten sensitivities, including celiac disease. Since the Paleolithic diet is devoid of cereal grains, it is free of gluten. The paleodiet is also casein-free. Casein is a protein found in milk and dairy products, which may impair glucose tolerance in humans.[4]

Compared to Paleolithic food groups, cereal grains and legumes contain high amounts of antinutrients, including alkylresorcinols, alpha-amylase inhibitors, protease inhibitors, lectins and phytates, substances known to interfere with the body's absorption of many key nutrients.[4][112][126] Molecular-mimicking proteins, which are basically made up of strings of amino acids that closely resemble those of another totally different protein, are also found in grains and legumes, as well as milk and dairy products.[4][112][126] Advocates of the Paleolithic diet have argued that these components of agrarian diets promote vitamin and mineral deficiencies and may explain the development of the "diseases of civilization" as well as a number of autoimmune-related diseases.[4][112][126]

Research

Archeological record

One line of evidence used to support the Stone Age diet is the decline in human health and body mass that occurred with the adoption of agriculture, at the end of the Paleolithic era.[21][126] Associated with the introduction of domesticated and processed plant foods, such as cereal grains, in the human diet, there was, in many areas, a general decrease in body stature and dentition size, and an increase in dental caries rates. There is evidence of a general decline in health in some areas; whether the decline was caused by dietary change is debated academically.[7][173][174]

Observational studies

Based on the subsistence patterns and biomarkers of hunter-gatherers studied in the last century, advocates argue that modern humans are well adapted to the diet of their Paleolithic ancestor.[175] The diet of modern hunter-gatherer groups is believed to be representative of patterns for humans of fifty to twenty-five thousand years ago,[175] and individuals from these and other technologically primitive societies,[176][177] including those individuals who reach the age of 60 or beyond,[39][178] seem to be largely free of the signs and symptoms of chronic disease (such as obesity, high blood pressure, nonobstructive coronary atherosclerosis, and insulin resistance) that universally afflict the elderly in western societies (with the exception of osteoarthritis, which afflicts both populations).[4][12][179] Moreover, when these people adopt western diets, their health declines and they begin to exhibit signs and symptoms of "diseases of civilization".[11][179] In one clinical study, stroke and ischaemic heart disease appeared to be absent in a population living on the island of Kitava, in Papua New Guinea, where a subsistence lifestyle, uninfluenced by western dietary habits, was still maintained.[39][180]

One of the most frequent criticisms of the Paleolithic diet is that it is unlikely that preagricultural hunter-gatherers suffered from the diseases of modern civilization simply because they did not live long enough to develop these illnesses, which are typically associated with old age.[12][17][181][182][183] According to S. Jay Olshansky and Bruce Carnes, "there is neither convincing evidence nor scientific logic to support the claim that adherence to a Paleolithic diet provides a longevity benefit."[183] In response to this argument, advocates of the paleodiet state that while Paleolithic hunter-gatherers did have a short average life expectancy, modern human populations with lifestyles resembling that of our preagricultural ancestors have little or no diseases of affluence, despite sufficient numbers of elderly.[12][184] In hunter-gatherer societies where demographic data is available, the elderly are present, but they tend to have high mortality rates and rarely survive past the age of 80, with causes of death (when known) ranging from injuries to measles and tuberculosis.[185]

Critics further contend that food energy excess, rather than the consumption of specific novel foods, such as grains and dairy products, underlies the diseases of affluence.[17][21][186] According to Geoffrey Cannon,[17] science and health policy advisor to the World Cancer Research Fund, humans are designed to work hard physically to produce food for subsistence and to survive periods of acute food shortage, and are not adapted to a diet rich in energy-dense foods.[187] Similarly, William R. Leonard, a professor of anthropology at Northwestern University, states that the health problems facing industrial societies stem not from deviations from a specific ancestral diet but from an imbalance between calories consumed and calories burned, a state of energy excess uncharacteristic of ancestral lifestyles.[186]

Intervention studies

The first animal experiment on a Paleolithic diet suggested that this diet, as compared with a cereal-based diet, conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure in 24 domestic pigs.[188] There was no difference in basal serum glucose.[188] The first human clinical randomized controlled trial involved 29 people with glucose intolerance and ischemic heart disease, and it found that those on a Paleolithic diet had a greater improvement in glucose tolerance compared to those on a Mediterranean diet.[13][189] Furthermore, the Paleolithic diet was found to be more satiating per calorie compared to the Mediterranean diet.[190]

A clinical, randomized, controlled cross-over study in the primary care setting compared the Paleolithic diet with a commonly prescribed diet for type 2 diabetes. The Paleolithic diet resulted in lower mean values of HbA1c, triacylglycerol, diastolic blood pressure, body mass index, waist circumference and higher values of high density lipoprotein when compared to the Diabetes diet. Also, glycemic control and other cardiovascular factors were improved in both diets without significant differences. It is also important to note that the Paleolithic diet was lower in total energy, energy density, carbohydrate, dietary glycemic load and glycemic index, saturated fatty acids and calcium, but higher in unsaturated fatty acids, dietary cholesterol and some vitamins.[191] Two clinical trials designed to test various physiological effects of the Paleolithic diet are currently underway,[192][193] and the results of one completed trial[194] have shown metabolic and physiologic improvements.[14] The European Journal of Clinical Nutrition published a study[195] of a trial of the Paleolithic diet in 20 healthy volunteers. The study had no control group, and only 14 individuals completed the diet. In the study, in three weeks there was an average weight reduction of 2.3 kg, an average reduction in waist circumference of 1.5 cm (about one-half inch), an average reduction in systolic blood pressure of 3 mm Hg, and a 72% reduction in plasminogen activator inhibitor-1 (which might translate into a reduced risk of heart attack and stroke.) However, the NHS Knowledge Service pointed out that this study, like most human diet studies, relied on observational data.The NHS concluded that the lack of a control group, and the small sample of size of the study, compromises their conclusions. With only 14 participants the study lacks the statistical power to detect health improvements, and perhaps the simple fact that these 14 individuals knew that they were on a diet program made them more aware of weight and exercise regime, skewing the results [196]

See also

References

  1. ^ a b c d e f g h i j k l m Lindeberg, Staffan (2005). "Palaeolithic diet ('stone age' diet)". Scandinavian Journal of Food & Nutrition. 49 (2): 75–7. doi:10.1080/11026480510032043. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Bryngelsson, Susanne; Asp, Nils-Georg (2005). "Popular diets, body weight and health: What is scientifically documented?". Scandinavian Journal of Food & Nutrition. 49 (1): 15–20. doi:10.1080/11026480510031990. {{cite journal}}: Unknown parameter |month= ignored (help)
  3. ^ a b c d e f g h i j k l Cordain, Loren (Summer 2002). "The Nutritional Characteristics of a Contemporary Diet Based Upon Paleolithic Food Groups" (PDF). Journal of the American Nutraceutical Association. 5 (5): 15–24.[unreliable medical source?]
  4. ^ a b c d e f g h i j k l Lindeberg, Staffan; Cordain, Loren; Eaton, S. Boyd (2003). "Biological and Clinical Potential of a Palaeolithic Diet". Journal of Nutritional and Environmental Medicine. 13 (3): 149–60. doi:10.1080/13590840310001619397. {{cite journal}}: Unknown parameter |month= ignored (help)
  5. ^ a b Voegtlin, Walter L. (1975). The stone age diet: Based on in-depth studies of human ecology and the diet of man. Vantage Press. ISBN 0-533-01314-3.[page needed] Cite error: The named reference "isbn0-533-01314-3" was defined multiple times with different content (see the help page).
  6. ^ a b Smith, Emma (October 12, 2008). "The Ray Mears caveman diet". The Sunday Times. Retrieved November 1, 2008. Cite error: The named reference "article4919415.ece" was defined multiple times with different content (see the help page).
  7. ^ a b c d e Richards, Michael P. (2002). "A brief review of the archaeological evidence for Palaeolithic and Neolithic subsistence". European Journal of Clinical Nutrition. 56 (12): 1270–78. doi:10.1038/sj.ejcn.1601646. PMID 12494313. {{cite journal}}: Unknown parameter |month= ignored (help)
  8. ^ a b Naugler, Christopher T. (2008). "Evolutionary medicine: Update on the relevance to family practice". Canadian Family Physician. 54 (9): 1265–9. PMC 2553465. PMID 18791103. {{cite journal}}: Unknown parameter |month= ignored (help)
  9. ^ a b Eaton, S.Boyd; Strassman, Beverly I; Nesse, Randolph M; Neel, James V; Ewald, Paul W; Williams, George C; Weder, Alan B; Eaton, Stanley B; Lindeberg, Staffan (2002). "Evolutionary Health Promotion". Preventive Medicine. 34 (2): 109–18. doi:10.1006/pmed.2001.0876. PMID 11817903.
  10. ^ a b c d e f g h i j k l m n Cordain, Loren; Eaton, S Boyd; Sebastian, Anthony; Mann, Neil; Lindeberg, Staffan; Watkins, Bruce A; O’Keefe, James H; Brand-Miller, Janette (2005). "Origins and evolution of the Western diet: health implications for the 21st century". American Journal of Clinical Nutrition. 81 (2): 341–54. PMID 15699220.
  11. ^ a b Kligler, Benjamin & Lee, Roberta A. (eds.) (2004). "Paleolithic diet". Integrative medicine. McGraw-Hill Professional. pp. 139–40. ISBN 0-07-140239-X. {{cite book}}: |author= has generic name (help); External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)CS1 maint: multiple names: authors list (link)
  12. ^ a b c d e Eaton, S.Boyd; Cordain, Loren; Lindeberg, Staffan (2002). "Evolutionary Health Promotion: A Consideration of Common Counterarguments". Preventive Medicine. 34 (2): 119–23. doi:10.1006/pmed.2001.0966. PMID 11817904.
  13. ^ a b Lindeberg S, Jönsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjöström K, Ahrén B (2007). "A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease" (PDF). Diabetologia. 50 (9): 1795–807. doi:10.1007/s00125-007-0716-y. PMID 17583796. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  14. ^ a b Frassetto, L A; Schloetter, M; Mietus-Synder, M; Morris, R C; Sebastian, A (2009). "Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet". European Journal of Clinical Nutrition. 63 (8): 947–55. doi:10.1038/ejcn.2009.4. PMID 19209185.
  15. ^ Eaton, S. Boyd (2007). "The ancestral human diet: What was it and should it be a paradigm for contemporary nutrition?". Proceedings of the Nutrition Society. 65 (1): 1–6. doi:10.1079/PNS2005471. PMID 16441938.
  16. ^ a b Nestle, Marion (1999). "Animal v. plant foods in human diets and health: is the historical record unequivocal?". Proceedings of the Nutrition Society. 58 (2): 211–18. doi:10.1017/S0029665199000300. PMID 10466159. {{cite journal}}: Unknown parameter |month= ignored (help)
  17. ^ a b c d e Cannon, Geoffrey (2006). "Out of the Box". Public Health Nutrition. 9 (4): 411–14. doi:10.1079/PHN2006959. {{cite journal}}: Unknown parameter |month= ignored (help)
  18. ^ a b c d e f Milton, Katharine (2002). "Hunter-gatherer diets: wild foods signal relief from diseases of affluence (PDF)". In Ungar, Peter S. & Teaford, Mark F. (ed.). Human Diet: Its Origins and Evolution. Westport, CT: Bergin and Garvey. pp. 111–22. ISBN 0-89789-736-6. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)CS1 maint: multiple names: editors list (link)
  19. ^ "Caveman fad diet".
  20. ^ a b c d Milton, Katharine (2000). "Hunter-gatherer diets—A different perspective". The American Journal of Clinical Nutrition. 71 (3): 665–67. PMID 10702155. {{cite journal}}: Unknown parameter |month= ignored (help)
  21. ^ a b c d e f g Elton, Sarah (2008). "Environments, Adaptation, and Evolutionary Medicine: Should We Be Eating a Stone Age Diet". In Elton, Sarah; O'Higgins, Paul (eds.). Medicine and Evolution: Current Applications, Future Prospects. London: Taylor and Francis. pp. 9–34. ISBN 978-1-4200-5134-6. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help) Cite error: The named reference "Elton2008" was defined multiple times with different content (see the help page).
  22. ^ a b c d e f g h i Ströhle, Alexander; Wolters, Maike; Hahn, Andreas (2007). "Carbohydrates and the diet–atherosclerosis connection—More between earth and heaven. Comment on the article 'The atherogenic potential of dietary carbohydrate'". Preventive Medicine. 44 (1): 82–4. doi:10.1016/j.ypmed.2006.08.014. PMID 16997359. {{cite journal}}: Unknown parameter |month= ignored (help)
  23. ^ a b c Nestle, Marion (2000). "Paleolithic diets: a sceptical view". Nutrition Bulletin. 25 (1): 43–7. doi:10.1046/j.1467-3010.2000.00019.x. {{cite journal}}: Unknown parameter |month= ignored (help)
  24. ^ a b c d e "Best Diets Overall". U.S.News & World Report. 2012.
  25. ^ "Paleo Diet". U.S.News & World Report. 2012.
  26. ^ Lindeberg, Staffan (2010). Food and Western Disease: Health and Nutrition from an Evolutionary Perspective. Chichester, U.K.: Wiley-Blackwell. ISBN 1-4051-9771-4. OCLC 435728298.[page needed]
  27. ^ Cordain, Loren (June 15, 2011). "Dr. Cordain's Rebuttal to U.S. News and World Report Top 20 Diets".[self-published source?]
  28. ^ a b Fallon, Sally (January 1, 2000). "Caveman Cuisine". Weston A. Price Foundation. {{cite web}}: |archive-url= requires |url= (help); Missing or empty |url= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help) Cite error: The named reference "westonaprice22" was defined multiple times with different content (see the help page).
  29. ^ "Functional and Structural Comparison of Man's Digestive Tract with that of a Dog and Sheep". Retrieved January 19, 2008.
  30. ^ Voegtlin, Walter L. (1975). The stone age diet: Based on in-depth studies of human ecology and the diet of man. Vantage Press. ISBN 0-533-01314-3.[page needed]
  31. ^ Audette, Ray V. (November 23, 1999). NeanderThin : Eat Like a Caveman to Achieve a Lean, Strong, Healthy Body. New York: St. Martin's Paperbacks. ISBN 0-312-97591-0. Archived from the original on Juli 19, 2011. Retrieved December 15, 2011. {{cite book}}: Check date values in: |archivedate= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)[page needed]
  32. ^ a b Eaton, S. Boyd; Konner, Melvin (1985). "Paleolithic Nutrition — A Consideration of Its Nature and Current Implications". The New England Journal of Medicine. 312 (5): 283–9. doi:10.1056/NEJM198501313120505. PMID 2981409.
  33. ^ Taylor, Mike (January 9, 2008). "Refined Food Bad! Caveman Diet Good!". TheStreet.com. Retrieved January 19, 2008.
  34. ^ Eaton, S. Boyd (1988). The Paleolithic Prescription: A Program of Diet & Exercise and a Design for Living. New York: Harper & Row. ISBN 0-06-015871-9. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)[non-primary source needed]
  35. ^ a b Sirota, Lorraine Handler; Greenberg, George (1989). "Book reviews". Biofeedback and Self-Regulation. 14 (4): 347–54. doi:10.1007/BF00999126.
  36. ^ Gilman, Sander L.; Bauber, Joe (2007). "Paleolithic diet". Diets and Dieting: A Cultural Encyclopedia. Routledge. pp. 209–11. ISBN 0-415-97420-8. {{cite book}}: Unknown parameter |editors= ignored (|editor= suggested) (help)CS1 maint: multiple names: authors list (link)
  37. ^ Eaton, S. Boyd (1989). Stone-Age Health Programme. Angus & Robertson Childrens. ISBN 0-207-16264-6. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)[non-primary source needed]
  38. ^ Vines, Gail (August 26, 1989). "Palaeolithic recipe for the clean life / Review of 'The Stone-Age Health Programme' by S. Boyd Eaton, Marjorie Shostak and Melvin Konner". New Scientist. Retrieved January 19, 2008.
  39. ^ a b c Lindeberg, S; & Lundh, B (1993). "Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in Kitava". Journal of Internal Medicine. 233 (3): 269–75. doi:10.1111/j.1365-2796.1993.tb00986.x. PMID 8450295. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  40. ^ "Kitava Study publications". PubMed, U.S. National Library of Medicine.[unreliable medical source?]
  41. ^ Lindeberg, Staffan (2003). Maten och folksjukdomarna — ett evolutionsmedicinskt perspektiv (in Swedish). Lund: Studentlitteratur. ISBN 91-44-04167-5. OCLC 186108854.[non-primary source needed]
  42. ^ Lindeberg, Staffan (2010). Food and Western Disease: Health and Nutrition from an Evolutionary Perspective. Chichester, U.K.: Wiley-Blackwell. ISBN 1-4051-9771-4. OCLC 435728298.
  43. ^ Eades, Michael R. & Eades, Mary Dan (2000). The Protein Power Lifeplan. New York: Warner Books. ISBN 0-446-60824-6.{{cite book}}: CS1 maint: multiple names: authors list (link)[page needed]
  44. ^ Atkins, Robert C. (1999). Dr Atkins' New Diet Revolution. Vermilion. ISBN 0-09-188948-0.[page needed]
  45. ^ Worm, Nicolai (2002). Syndrom X oder ein Mammut auf den Teller. Mit Steinzeit-Diät aus det Wohl stands Falle (in German). Lünen: Systemed-Verlag. ISBN 3-927372-23-4.[page needed]
  46. ^ a b Audette, Ray V. (November 23, 1999). NeanderThin : Eat Like a Caveman to Achieve a Lean, Strong, Healthy Body. New York: St. Martin's Paperbacks. ISBN 0-312-97591-0. Archived from the original on Juli 19, 2011. Retrieved December 15, 2011. {{cite book}}: Check date values in: |archivedate= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  47. ^ Cordain, Loren (2002). The Paleo Diet: Lose Weight and Get Healthy by Eating the Food You Were Designed to Eat. New York: Wiley. ISBN 0-471-26755-4.[page needed]
  48. ^ Cordain, Loren & Friel, Joe (2005). The Paleo Diet for Athletes: A Nutritional Formula for Peak Athletic Performance. Rodale Books. ISBN 1-59486-089-0.{{cite book}}: CS1 maint: multiple names: authors list (link)[page needed]
  49. ^ Wiss, Don. "Paleo Diet". The Paleolithic Diet Nutrition Page. Archived from the original on January 9, 1997. Retrieved December 15, 2011.
  50. ^ Lindeberg, Staffan. "Home". Paleolithic Diet in Medical Nutrition. Retrieved January 19, 2008.
  51. ^ Cordain, Loren. "The Science of Healthy Eating". The Paleo Diet. Retrieved January 19, 2008.
  52. ^ James, Abel. "Is The Paleo Diet Too Extreme? What if I Don't Want to be a Caveman?". The LeanBody Lifestyle. Retrieved March 1, 2012.
  53. ^ Vogin, Gary (2000). "Eating Like a Caveman". WebMD. Retrieved August 3, 2008.
  54. ^ Burfoot, Amby (February 11, 2005). "Should you be eating like a Caveman?". Runner's World. Retrieved January 19, 2008.
  55. ^ Shreeve, Jimmy Lee (August 16, 2007). "The Stone Age Diet: Why I Eat Like a Caveman". Independent UK. Retrieved January 19, 2008.
  56. ^ Tuttle, Erica (September 4, 2000). "Revolutionary Evolutionary Diets". FindArticles. Retrieved January 19, 2008.
  57. ^ Mysterud, Iver (May 20, 2004). "Kosthold og evolusjon". Tidsskr nor Lægeforen (in Swedish). 124 (10): 1415.
  58. ^ Cordain, Loren. "A Sample of Paleo Recipes". The Paleo Diet. Archived from the original on January 11, 2008. Retrieved January 19, 2008.
  59. ^ Lindeberg, Staffan. "Frequently Asked Questions: What can I eat?". Paleolithic Diet in Medical Nutrition. Retrieved January 19, 2008.
  60. ^ a b c d e f O'Keefe, James H.; & Cordain, Loren (2004). "Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer" (PDF). Mayo Clinic Proceedings. 79 (1): 101–08. doi:10.4065/79.1.101. PMID 14708953. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  61. ^ a b c Lindeberg, Staffan (2009). "Modern human physiology with respect to evolutionary adaptations that relate to diet in the past". The Evolution of Hominin Diets: Integrating Approaches to the Study of Palaeolithic Subsistence. Springer. ISBN 978-1-4020-9698-3. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help); Unknown parameter |editors= ignored (|editor= suggested) (help)
  62. ^ Cordain, Loren (2006). "Implications of Plio-Pleistocene Hominin Diets for Modern Humans (PDF)". In Ungar, Peter S. (ed.). Evolution of the Human Diet: The Known, the Unknown, and the Unknowable. Oxford, USA: Oxford University Press. pp. 363–83. ISBN 0-19-518346-0. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
  63. ^ The Paleolithic/Paleo/Caveman/Primal Diet Defined
  64. ^ Cordain L, Watkins BA, Florant GL, Kelher M, Rogers L, Li Y (2002). "Fatty acid analysis of wild ruminant tissues: evolutionary implications for reducing diet-related chronic disease". European Journal of Clinical Nutrition. 56 (3): 181–91. doi:10.1038/sj.ejcn.1601307. PMID 11960292. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  65. ^ Archevore - Archevore Diet
  66. ^ Archevore - Archevore Blog - Health and Evolutionary Reasoning – The PaNu Method
  67. ^ a b Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J (1 August 2005). "Reply to SC Cunnane" (PDF). The American Journal of Clinical Nutrition. 82 (2): 483–84. PMID 16087997.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  68. ^ Eaton, S. Boyd (2006). "Preagricultural Diets and Evolutionary Health Promotion". In Peter Ungar (ed.). Evolution of the Human Diet: The Known, the Unknown, and the Unknowable. Oxford, USA: Oxford University Press. p. 400. ISBN 0-19-518346-0. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
  69. ^ Raw Paleolithic Diet & Lifestyle — Raw Paleo Lifestyle for Health
  70. ^ Raw Paleo Diet - RVAF Systems Overview
  71. ^ a b Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD (1 March 2000). "Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets". The American Journal of Clinical Nutrition. 71 (3): 682–92. PMID 10702160.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  72. ^ a b c d e Cordain L, Eaton SB, Miller JB, Mann N, Hill K (2002). "The paradoxical nature of hunter-gatherer diets: meat based, yet non-atherogenic" (PDF). European Journal of Clinical Nutrition. 56 (Suppl 1): S42–52. doi:10.1038/sj.ejcn.1601353. PMID 11965522. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  73. ^ a b c Eaton SB, Eaton SB 3rd, Konner MJ (1997). "Paleolithic nutrition revisited: a twelve-year retrospective on its nature and implications" (PDF). European Journal of Clinical Nutrition. 51 (4): 207–16. doi:10.1038/sj.ejcn.1600389. PMID 9104571.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  74. ^ Eaton SB, Cordain L, Eaton SB (2001). "An evolutionary foundation for health promotion" (PDF). World Review of Nutrition and Dietetics. World Review of Nutrition and Dietetics. 90: 5–12. doi:10.1159/000059815. ISBN 3-8055-7211-5. PMID 11545045.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  75. ^ Frank W Booth; et al. (2002). "Exercise and gene expression: physiological regulation of the human genome through physical activity". J Physiol. 543 (Pt 2): 399–411. doi:10.1113/jphysiol.2002.019265. PMC 2290514. PMID 12205177. {{cite journal}}: Unknown parameter |author-separator= ignored (help)
  76. ^ a b Cordain L; et al. (1998). "Physical activity, energy expenditure and fitness: an evolutionary perspective" (PDF). International Journal of Sports Medicine. {{cite journal}}: Unknown parameter |author-separator= ignored (help)
  77. ^ S. Boyd Eaton; et al. (2009). "Evolution, body composition, insulin receptor competition, and insulin resistance" (PDF). Preventive Medicine. {{cite journal}}: Unknown parameter |author-separator= ignored (help)
  78. ^ <Please add first missing authors to populate metadata.>. doi:10.1152/japplphysiol.00757.2003. PMID 14660491. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  79. ^ W. H. M. Saris (2003). "How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement" (PDF). Obesity. {{cite journal}}: Invalid |display-authors=1 (help); Unknown parameter |author-separator= ignored (help)
  80. ^ Eaton, SB; Eaton, SB (2003). "An evolutionary perspective on human physical activity: Implications for health". Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 136 (1): 153–9. doi:10.1016/S1095-6433(03)00208-3. PMID 14527637.
  81. ^ Gray, Russell D. (2001). "Selfish genes or developmental systems?". In Singh, Rama S.; Krimbas, Costas B.; Paul, Diane B.; & Beatty, John (ed.). Thinking about Evolution: Historical, Philosophical and Political Perspectives. Cambridge: Cambridge University Press. pp. 184–207. ISBN 0-521-62070-8.{{cite book}}: CS1 maint: multiple names: editors list (link)
  82. ^ Wilson, David S. (1994). "Adaptive genetic variation and human evolutionary psychology". Ethology and Sociobiology. 15 (4): 219–35. doi:10.1016/0162-3095(94)90015-9.
  83. ^ a b Kopp, Wolfgang (2007). "Reply to the comment of Ströhle et al". Preventive Medicine. 44 (1): 84–5. doi:10.1016/j.ypmed.2006.09.003. {{cite journal}}: Unknown parameter |month= ignored (help)
  84. ^ Hawks J, Wang ET, Cochran GM, Harpending HC, Moyzis RK (2007). "Recent acceleration of human adaptive evolution". Proc Natl Acad Sci U S A. 104 (52): 20753–8. doi:10.1073/pnas.0707650104. PMC 2410101. PMID 18087044. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  85. ^ Mahner, Martin; & Bunge, Mario (2001). "Function and functionalism: a synthetic perspective". Philosophy of Science. 68 (1): 75–94. doi:10.1086/392867.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  86. ^ a b Ströhle, Alexander; & Hahn, Andreas (2006). "Evolutionary nutrition science and dietary recommendations of the Stone Age—The ideal answer to present-day nutritional questions or reason for criticism? Part 1: Concept, arguments and paleoanthropological findings" (PDF). Ernährungs-Umschau (in German). 53 (1): 10–16.{{cite journal}}: CS1 maint: multiple names: authors list (link) Abstract (in English)
  87. ^ Milton, Katharine; & Demment, Montague W. (1 September 1988). "Digestion and passage kinetics of chimpanzees fed high and low fiber diets and comparison with human data" (PDF). Journal of Nutrition. 118 (9): 1082–88. PMID 2843616.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  88. ^ Milton, Katharine (1999). "Nutritional characteristics of wild primate foods: do the diets of our closest living relatives have lessons for us?" (PDF). Nutrition. 15 (6): 488–98. doi:10.1016/S0899-9007(99)00078-7. PMID 10378206. {{cite journal}}: Unknown parameter |month= ignored (help)
  89. ^ a b Milton, Katharine (1999). "A hypothesis to explain the role of meat-eating in human evolution" (PDF). Evolutionary Anthropology. 8 (1): 11–21. doi:10.1002/(SICI)1520-6505(1999)8:1<11::AID-EVAN6>3.0.CO;2-M.
  90. ^ a b Milton, Katharine (2000). "Back to basics: why foods of wild primates have relevance for modern human health" (PDF). Nutrition. 16 (7–8): 481–83. doi:10.1016/S0899-9007(00)00293-8. PMID 10906529.
  91. ^ Piperno, D (2004). "Processing of wild cereal grains in the Upper Paleolithic revealed by starch grain analysis" (PDF). Nature. 430 (7000): 670–673. doi:10.1038/nature02734. PMID 15295598. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  92. ^ Aranguren, B (2007). "Grinding flour in Upper Palaeolithic Europe (25 000 years bp)". Antiquity. 81: 845–855. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  93. ^ Revedin, Anna; Aranguren, B; Becattini, R; Longo, L; Marconi, E; Lippi, MM; Skakun, N; Sinitsyn, A; Spiridonova, E (2010). "Thirty thousand-year-old evidence of plant food processing". Proc Natl Acad Sci U S A. 107 (44): 18815–9. doi:10.1073/pnas.1006993107. PMC 2973873. PMID 20956317.
  94. ^ Julio Mercader (2009) 'Mozambican Grass Seed Consumption During the Middle Stone Age', Science, 18 December 2009.
  95. ^ Murphy, D (2007). People, Plants and Genes: The Story of Crops and Humanity. Oxford: Oxford University Press. ISBN 0-19-920713-5.
  96. ^ a b Marlowe FW (2005). "Hunter-gatherers and human evolution" (PDF). Evolutionary Anthropology. 14 (2): 15294. doi:10.1002/evan.20046.
  97. ^ Kolbert, Elizabeth. "Flesh of Your Flesh", The New Yorker, November 9, 2009, accessed January, 27, 2011.
  98. ^ African Bone Tools Dispute Key Idea About Human Evolution National Geographic News article.
  99. ^ Collins, Desmond (1973). Background to archaeology: Britain in its European setting (Revised ed.). Cambridge University Press. ISBN 0-521-20155-1.
  100. ^ Donna Hart, Robert W. Sussman. Man the Hunted. ISBN 0-8133-3936-7.
  101. ^ "The Diet of Early Humans: What did our ancestors eat?".
  102. ^ Diamond, Jared (2006). The rise and fall of the third chimpanzee. p. 40. ISBN 978-0-09-174268-3.
  103. ^ "Chimp hunting and flesh-eating".
  104. ^ "Chimpanzees 'hunt using spears'". BBC News. February 22, 2007.
  105. ^ Leslie C. Aiello, Peter Wheeler (1995). "The expensive-tissue hypothesis" (PDF). Current Anthropology.
  106. ^ Kris-Etherton, PM; Harris, WS; Appel, LJ; Nutrition, Committee (2003). "Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease". Arteriosclerosis, thrombosis, and vascular biology. 23 (2): e20–30. doi:10.1161/01.ATV.0000038493.65177.94. PMID 12588785.
  107. ^ a b Crawford, M. A.; et al. (1999). "Evidence for the Unique Function of Docosahexaenoic Acid (DHA) During the Evolution of the Modern Hominid Brain" (PDF). Lipids: S39–S47.
  108. ^ a b c Cordain, L.; Watkins, B. A.; Mann, N. J. (2001). "Fatty acid composition and energy density of foods available to African hominids: evolutionary implications for human brain development". World Review of Nutrition and Dietetics: 144–161.
  109. ^ "Dietary Fats: Total Fat and Fatty Acids" (PDF).
  110. ^ Bryce A. Carlson and John D. Kingston (2007). "Docosahexaenoic Acid Biosynthesis and Dietary Contingency: Encephalization Without Aquatic Constraint". {{cite journal}}: Cite journal requires |journal= (help)
  111. ^ Fairweather-Tait, Susan J. (October 29, 2003). "Human nutrition and food research: opportunities and challenges in the post-genomic era". Phil. Trans. R. Soc. B. 358 (1438): 1709–27. doi:10.1098/rstb.2003.1377. PMC 1693270. PMID 14561328.
  112. ^ a b c d Jönsson T, Olsson S, Ahrén B, Bøg-Hansen TC, Dole A, Lindeberg S (2005). "Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?". BMC Endocrine Disorders. 5: 10. doi:10.1186/1472-6823-5-10. PMC 1326203. PMID 16336696.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  113. ^ Leach, Jeff D. (2007). "Prebiotics in Ancient Diet". Food Science and Technology Bulletin. 4 (1): 1–8. doi:10.1616/1476-2137.14801.
  114. ^ Collins, Christopher (January–March 2007). "Said Another Way: Stroke, Evolution, and the Rainforests: An Ancient Approach to Modern Health Care". Nursing Forum. 42 (1): 39–44. doi:10.1111/j.1744-6198.2007.00064.x. PMID 17257394.
  115. ^ Bellisari A. (2008). "Evolutionary origins of obesity". Obesity Reviews. 9 (2): 165–180. doi:10.1111/j.1467-789X.2007.00392.x. PMID 18257754. {{cite journal}}: Unknown parameter |month= ignored (help)
  116. ^ Strandvik, B. Eriksson, S. Garemo, M. Palsdottir, V. Samples, S. Pickova, J (March 4, 2008). "Is the relatively low intake of omega-3 fatty acids in Western diet contributing to the obesity epidemics?". Lipid Technology. 20 (3): 57–59. doi:10.1002/lite.200800009.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  117. ^ Wood LE (2006). "Obesity, waist–hip ratio and hunter–gatherers". BJOG: an International Journal of Obstetrics & Gynaecology. 113 (10): 1110–16. doi:10.1111/j.1471-0528.2006.01070.x. PMID 16972857. {{cite journal}}: Unknown parameter |month= ignored (help)
  118. ^ O'Keefe JH Jr, Cordain L, Harris WH, Moe RM, Vogel R (2004). "Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal". Journal of the American College of Cardiology. 43 (11). American College of Cardiology: 2142–46. doi:10.1016/j.jacc.2004.03.046. PMID 15172426. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  119. ^ O'Keefe JH Jr, Cordain L, Jones PG, Abuissa H. (2006). "Coronary artery disease prognosis and C-reactive protein levels improve in proportion to percent lowering of low-density lipoprotein". The American Journal of Cardiology. 98 (1): 135–39. doi:10.1016/j.amjcard.2006.01.062. PMID 16784936. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  120. ^ a b Kopp, Wolfgang (2006). "The atherogenic potential of dietary carbohydrate". Preventive Medicine. 42 (5): 336–42. doi:10.1016/j.ypmed.2006.02.003. PMID 16540158. {{cite journal}}: Unknown parameter |month= ignored (help)
  121. ^ Tekol, Yalcin (2008). "Maternal and infantile dietary salt exposure may cause hypertension later in life". Birth Defects Research Part B: Developmental and Reproductive Toxicology. 83 (2): 77–79. doi:10.1002/bdrb.20149. PMID 18330898. {{cite journal}}: Unknown parameter |month= ignored (help)
  122. ^ Dedoussis GV, Kaliora AC, Panagiotakos DB (Spring 2007). "Genes, Diet and Type 2 Diabetes Mellitus: A Review". Review of Diabetic Studies. 4 (1): 13–24. doi:10.1900/RDS.2007.4.13. PMC 1892523. PMID 17565412.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  123. ^ Haag, Marianne; & Dippenaar, Nola (2005). "Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection". Medical Science Monitor. 11 (12): RA359–367. PMID 16319806.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  124. ^ a b Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr (1 December 2002). "Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors". The American Journal of Clinical Nutrition. 76 (6): 1308–16. PMID 12450898.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  125. ^ a b Morris RC Jr, Schmidlin O, Frassetto LA, Sebastian A (2006). "Relationship and interaction between sodium and potassium". Journal of the American College of Nutrition. 25 (3): 262S–70S. PMID 16772638. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  126. ^ a b c d e f Cordain, Loren (1999). "Cereal grains: humanity's double-edged sword" (PDF). World review of nutrition and dietetics. World Review of Nutrition and Dietetics. 84: 19–73. doi:10.1159/000059677. ISBN 3-8055-6827-4. PMID 10489816.
  127. ^ Bostick, Roberd M. (2001). "Diet and nutrition in the etiology and primary prevention of colon cancer". Preventive Nutrition: The Comprehensive Guide for Health Professionals. Humana Press. pp. 47–98. ISBN 0-89603-911-0. {{cite book}}: Unknown parameter |editors= ignored (|editor= suggested) (help)
  128. ^ Lawlor, Debbie A; & Ness, Andy R (2003). "Commentary: The rough world of nutritional epidemiology: Does dietary fibre prevent large bowel cancer?". International Journal of Epidemiology. 32 (2): 239–43. doi:10.1093/ije/dyg060. PMID 12714543. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  129. ^ Leach, Jeff D. (2007). "Evolutionary perspective on dietary intake of fibre and colorectal cancer". European Journal of Clinical Nutrition. 61 (1): 140–42. doi:10.1038/sj.ejcn.1602486. PMID 16855539. {{cite journal}}: Unknown parameter |month= ignored (help)
  130. ^ Cordain L, Eaton SB, Brand Miller J, Lindeberg S, Jensen C (2002). "An evolutionary analysis of the etiology and pathogenesis of juvenile-onset myopia". Acta Ophthalmologica Scandinavica. 80 (2): 125–35. doi:10.1034/j.1600-0420.2002.800203.x. PMID 11952477. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  131. ^ Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J (2002). "Acne vulgaris: a disease of Western civilization". Archives of Dermatology. 138 (12): 1584–90. doi:10.1001/archderm.138.12.1584. PMID 12472346. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  132. ^ Cordain, Loren (2005). "Implications for the role of diet in acne" (PDF). Seminars in Cutaneous Medicine and Surgery. 24 (2): 84–91. doi:10.1016/j.sder.2005.04.002. PMID 16092796. {{cite journal}}: Unknown parameter |month= ignored (help)
  133. ^ Cordain, Loren (2006). "Dietary implications for the development of acne: a shifting paradigm (PDF)". In Bedlow, J. (ed.). US Dermatology Review 2006—Issue II. London: Touch Briefings Publications. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
  134. ^ Keri, Jonette E; Nijhawan, Rajiv (2008). "Diet and acne". Expert Review of Dermatology. 3 (4): 437–40. doi:10.1586/17469872.3.4.437. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  135. ^ Volker, Dianne; & NG, Jade (2006). "Depression: Does nutrition have an adjunctive treatment role?" (PDF). Nutrition & Dietetics. 63 (4): 213–226. doi:10.1111/j.1747-0080.2006.00109.x. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  136. ^ a b Cunnane, Stephen C. (1 August 2005). "Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain". The American Journal of Clinical Nutrition. 82 (2): 483, author reply 483–4. PMID 16087997.
  137. ^ Solomons, Noel W (2008). "National food fortification: a dialogue with reference to Asia: balanced advocacy" (PDF). Asia Pacific Journal of Clinical Nutrition. 17 (Suppl 1): 20–3. PMID 18296293.
  138. ^ Friis, Henrik (2007). "International nutrition and health". Danish Medical Bulletin. 54 (1): 55–7. PMID 17349228. {{cite journal}}: Unknown parameter |month= ignored (help)
  139. ^ Mann, Neil (2007). "Meat in the human diet: an anthropological perspective" (PDF). Nutrition & Dietetics. 64 (4): S102–S107. doi:10.1111/j.1747-0080.2007.00194.x. {{cite journal}}: Unknown parameter |month= ignored (help)
  140. ^ Cordain L, Miller JB, Eaton SB, Mann N (1 December 2000). "Macronutrient estimations in hunter-gatherer diets". The American Journal of Clinical Nutrition. 72 (6): 1589–92. PMID 11101497.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  141. ^ Westman EC, Feinman RD, Mavropoulos JC, Vernon MC, Volek JS, Wortman JA, Yancy WS, Phinney SD (1 August 2007). "Low-carbohydrate nutrition and metabolism". The American Journal of Clinical Nutrition. 86 (2): 276–84. PMID 17684196.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  142. ^ Colagiuri, Stephen; & Brand-Miller, Jennie (2002). "The 'carnivore connection'—evolutionary aspects of insulin resistance" (PDF). European Journal of Clinical Nutrition. 56 (1): S30–5. doi:10.1038/sj.ejcn.1601351. PMID 11965520. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  143. ^ Plaskett, L. G. (2003). "On the Essentiality of Dietary Carbohydrate". Journal of Nutritional & Environmental Medicine. 13 (3): 161–168. doi:10.1080/13590840310001619405. {{cite journal}}: Unknown parameter |month= ignored (help)
  144. ^ Pérez-Guisado, J (2008). "Ketogenic diets: Additional benefits to the weight loss and unfounded secondary effects". Archivos latinoamericanos de nutricion. 58 (4): 323–9. PMID 19368291.
  145. ^ Westman, EC; Yancy Jr, WS; Mavropoulos, JC; Marquart, M; McDuffie, JR (2008). "The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus". Nutrition & metabolism. 5: 36. doi:10.1186/1743-7075-5-36. PMC 2633336. PMID 19099589.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  146. ^ Ungar, Peter S.; Grine, Frederick E.; & Teaford, Mark F. (October 2006). "Diet in Early Homo: A Review of the Evidence and a New Model of Adaptive Versatility" (PDF). Annual Review of Anthropology. 35 (1): 209–228. doi:10.1146/annurev.anthro.35.081705.123153.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  147. ^ Milton, Katharine; Miller, JB; Eaton, SB; Mann, N (1 December 2000). "Reply to L Cordain et al" (PDF). The American Journal of Clinical Nutrition. 72 (6): 1590–92. PMID 11101497.
  148. ^ Walker, Alexander RP (1 February 2001). "Are health and ill-health lessons from hunter-gatherers currently relevant?". The American Journal of Clinical Nutrition. 73 (2): 353–56. PMID 11157335.
  149. ^ Cordain, Loren (2006). "Saturated fat consumption in ancestral human diets: implications for contemporary intakes". In Meskin, Mark S.; Bidlack, Wayne R.; & Randolph, R. Keith (ed.). Phytochemicals: Nutrient-Gene Interactions. CRC Press. pp. 115–26. ISBN 0-8493-4180-9. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)CS1 maint: multiple names: editors list (link)
  150. ^ Simopoulos, Artemis P. (2006). "Evolutionary aspects of diet, the omega-6:omega-3 ratio, and gene expression". Phytochemicals: Nutrient-Gene Interactions. CRC Press. pp. 137–160. ISBN 0-8493-4180-9. {{cite book}}: Unknown parameter |editors= ignored (|editor= suggested) (help)
  151. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15023647 , please use {{cite journal}} with |pmid= 15023647 instead.
  152. ^ a b Longe, Jacqueline L. (2007). The Gale Encyclopedia of Diets: A Guide to Health and Nutrition. Gale Cengage. ISBN 1-4144-2991-6.
  153. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20042527 , please use {{cite journal}} with |pmid= 20042527 instead.
  154. ^ Prentice, A. M.; Jebb, S. A. (2003). "Fast foods, energy density and obesity: A possible mechanistic link". Obesity Reviews. 4 (4): 187–94. doi:10.1046/j.1467-789X.2003.00117.x. PMID 14649369.
  155. ^ Rolls, Barbara. The Volumetrics Eating Plan: Techniques and Recipes for Feeling Full on Fewer Calories. ISBN 0-06-073730-1.[page needed]
  156. ^ "McDonald's USA Nutrition Facts for Popular Menu Items" (PDF). McDonald's. March 12, 2012.
  157. ^ Bell, Elizabeth A; Castellanos, Victoria H; Pelkman, Christine L; Thorwart, Michelle L; Rolls, Barbara J (1998). "Energy density of foods affects energy intake in normal-weight women". The American Journal of Clinical Nutrition. 67 (3): 412–20. PMID 9497184.
  158. ^ Drewnowski, Adam; Darmon, Nicole (2005). "The economics of obesity: Dietary energy density and energy cost". The American Journal of Clinical Nutrition. 82 (1 Suppl): 265S–273S. PMID 16002835.
  159. ^ Ello-Martin, Julia A; Roe, Liane S; Ledikwe, Jenny H; Beach, Amanda M; Rolls, Barbara J (2007). "Dietary energy density in the treatment of obesity: A year-long trial comparing 2 weight-loss diets". The American Journal of Clinical Nutrition. 85 (6): 1465–77. PMC 2018610. PMID 17556681.
  160. ^ Heaney, Robert P. (2001). "Calcium intake and the prevention of chronic disease". Nutritional Health: Strategies for Disease Prevention. Humana Press. pp. 31–50. ISBN 0-89603-864-5. {{cite book}}: Unknown parameter |editors= ignored (|editor= suggested) (help)
  161. ^ Heaney, Robert P. (2006). "Calcium intake and disease prevention". Arquivos Brasileiros de Endocrinologia & Metabologia. 50 (4): 685–693. doi:10.1590/S0004-27302006000400014. {{cite journal}}: Unknown parameter |month= ignored (help)
  162. ^ Heaney, Robert P. (2006). "Calcium metabolism". In Schulz, Richard (ed.). Encyclopedia of Aging: A Comprehensive Resource in Gerontology and Geriatrics. Springer. pp. 146–147. ISBN 0-8261-4843-3.
  163. ^ "Dietary Supplement Fact Sheet: Vitamin D". Office of Dietary Supplements (ODS). National Institutes of Health (NIH). Retrieved 2010-04-11.
  164. ^ Paul Insel, Don Ross, Kimberley McMahon, Melissa Bernstein (2010). Nutrition. p. 410. ISBN 0-7637-7663-7.{{cite book}}: CS1 maint: multiple names: authors list (link)
  165. ^ S. Boyd Eaton, Stanley B. Eaton III, Andrew J. Sinclair, Loren Cordain, Neil J. Mann (1998). "Dietary intake of long-chain polyunsaturated fatty acids during the Paleolithic" (PDF). World Rev Nutr Diet.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  166. ^ Foster-Powell K, Holt SH, Brand-Miller J (1 July 2002). "International table of glycemic index and glycemic load values: 2002". The American Journal of Clinical Nutrition. 76 (1): 5–56. PMID 12081815.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  167. ^ Liljeberg Elmståhl H.; & Björck, Inger ME (2001). "Milk as a supplement to mixed meals may elevate postprandial insulinaemia" (PDF). European journal of clinical nutrition. 55 (11): 994–99. doi:10.1038/sj.ejcn.1601259. PMID 11641749.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  168. ^ Hoyt G, Hickey MS, Cordain L (2005). "Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk". British Journal of Nutrition. 93 (2): 175–77. doi:10.1079/BJN20041304. PMID 15788109.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  169. ^ Östman E Liljeberg H Björck. "Inconsistency between glycemic and insulinemic responses to" (PDF). Retrieved 6 September 2011.
  170. ^ Cordain L, Eades MR, Eades MD (2003). "Hyperinsulinemic diseases of civilization: more than just Syndrome X" (PDF). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 136 (1): 95–112. doi:10.1016/S1095-6433(03)00011-4. PMID 14527633.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  171. ^ Frassetto LA, Morris RC Jr, Sellmeyer DE, Sebastian A (2008). "Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets". Journal of Nutrition. 138 (2): 419S–22S. PMID 18203914. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  172. ^ Frassetto LA, Morris RC Jr, Sebastian A (2006). "A practical approach to the balance between acid production and renal acid excretion in humans". Journal of Nephrology. 9 (19): 33–40. PMID 16736439.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  173. ^ Larsen, Clark Spencer (1 November 2003). "Animal source foods and human health during evolution". Journal of Nutrition. 133 (11, Suppl 2): 3893S–3897S. PMID 14672287.
  174. ^ Hermanussen, Michael; Poustka, Fritz (2003). "Stature of early Europeans". Hormones (Athens). 2 (3): 175–8. doi:10.1159/000079404. PMID 17003019. {{cite journal}}: Unknown parameter |month= ignored (help)
  175. ^ a b Eaton, S. Boyd (2007). "The Ancestral Biomedical Environment (PDF)". In Aird, William C. (ed.). Endothelial Biomedicine. Cambridge University Press. pp. 129–34. ISBN 0-521-85376-1. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  176. ^ Eaton SB, Konner M, Shostak M (1988). "Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective" (PDF). The American Journal of Medicine. 84 (4): 739–49. doi:10.1016/0002-9343(88)90113-1. PMID 3135745. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  177. ^ Eaton, S. Boyd & Eaton, Stanley. B 3rd (1999). "The evolutionary context of chronic degenerative diseases". In Stearns, Stephen C. (ed.). Evolution in health and disease. Oxford: Oxford University Press. pp. 251–59. ISBN 0-19-850445-4.{{cite book}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)
  178. ^ Trowell, Hugh C. & Burkett, Denis P. (1981). Western diseases: their emergence and prevention. Cambridge, MA: Harvard University Press. xiii–xvi. ISBN 0-674-95020-8. {{cite book}}: Unknown parameter |nopp= ignored (|no-pp= suggested) (help)CS1 maint: multiple names: authors list (link)
  179. ^ a b Eaton, S. Boyd (2007). "The Ancestral Biomedical Environment (PDF)". In Aird, William C. (ed.). Endothelial Biomedicine. Cambridge University Press. pp. 129–34. ISBN 0-521-85376-1. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  180. ^ Lindeberg S, Eliasson M, Lindahl B, Ahrén B (1999). "Low serum insulin in traditional Pacific Islanders—The Kitava study". Metabolism. 48 (10): 1216–19. doi:10.1016/S0026-0495(99)90258-5. PMID 10535381. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  181. ^ Solomons, Noel W. (1 March 2000). "Book Review—Evolutionary Aspects of Nutrition and Health: Diet, Exercise, Genetics and Chronic Disease". The American Journal of Clinical Nutrition. 71 (3): 854–55.
  182. ^ Cannon, Geoffrey (2007). "Drugs and bugs, and other stories [Out of the Box]". Public Health Nutrition. 10 (8): 758–61. doi:10.1017/S1368980007770568. {{cite journal}}: Unknown parameter |month= ignored (help)
  183. ^ a b Olshansky, S. Jay; Carnes, Bruce A. (2002). The Quest for Immortality: Science at the Frontiers of Aging. W. W. Norton & Company. pp. 188–191. ISBN 0-393-32327-7.{{cite book}}: CS1 maint: multiple names: authors list (link)
  184. ^ Leach, Jeff D. (2007). "Paleo Longevity Redux (Letters to the Editor)". Public Health Nutrition. 10 (11). doi:10.1017/S1368980007814492.
  185. ^ Michael Gurven, Hillard Kaplan. "Longevity Among Hunter-Gatherers: A Cross-Cultural Examination". {{cite web}}: Missing or empty |url= (help) | url = http://www.anth.ucsb.edu/faculty/gurven/papers/GurvenKaplan2007pdr.pdf
  186. ^ a b Leonard, William R. (2002). "Food for thought: Dietary change was a driving force in human evolution" (PDF). Scientific American. 287 (6): 106–15. PMID 12469653. {{cite journal}}: Unknown parameter |month= ignored (help)
  187. ^ Uauy, Ricardo; & Díaz, Erik (2005). "Consequences of food energy excess and positive energy balance". Public Health Nutrition. 8 (7A): 1077–99. doi:10.1079/PHN2005797. PMID 16277821. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  188. ^ a b Jönsson T, Ahrén B, Pacini G, Sundler F, Wierup N, Steen S, Sjöberg T, Ugander M, Frostegård J, Göransson L, Lindeberg S (2006). "A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs". Nutrition & Metabolism. 3 (39): 39. doi:10.1186/1743-7075-3-39. PMC 1635051. PMID 17081292.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  189. ^ Magnusson, Per A (December 18, 2007). "Paleolitisk kost ger bättre glukostolerans än medelhavskost". Läkartidningen (in Swedish). 104 (51–52): 3852.
  190. ^ Jönsson T, Granfeldt Y, Erlanson-Albertsson C, Ahrén B, Lindeberg S (2010). "A Paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart disease" (PDF). Nutr Metab (Lond). 7 (1): 85. doi:10.1186/1743-7075-7-85. PMC 3009971. PMID 21118562. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  191. ^ Jonsson T, Granfeldt Y, Ahren B, Branell UC, Palsson G, Hansson A, Lindeberg S (2009). "Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study". Cardiovascular Diabetology. 8 (1): 35–49. doi:10.1186/1475-2840-8-35. PMC 2724493. PMID 19604407.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  192. ^ Clinical trial number NCT00548782 for "Paleolithic Diet and Exercise Study" at ClinicalTrials.gov
  193. ^ Clinical trial number NCT00692536 for "Diet Composition - Metabolic Regulation and Long-term Compliance (KNOTA)" at ClinicalTrials.gov
  194. ^ Clinical trial number NCT00360516 for "Paleolithic Diet and Exercise Study" at ClinicalTrials.gov
  195. ^ Osterdahl M, Kocturk T, Koochek A, Wändell PE (2008). "Effects of a short-term intervention with a Paleolithic diet in healthy volunteers". European Journal of Clinical Nutrition. 62 (5): 682–85. doi:10.1038/sj.ejcn.1602790. PMID 17522610. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  196. ^ NHS Knowledge Service (May 9, 2008). "Caveman fad diet". NHS Choices. Retrieved August 1, 2008.
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