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Dexbrompheniramine

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Dexbrompheniramine
Clinical data
Trade namesDrixoril, Conex, Dixaphedrine
AHFS/Drugs.comMultum Consumer Information
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life25 hours
Identifiers
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.595 Edit this at Wikidata
Chemical and physical data
FormulaC16H19BrN2
Molar mass319.246 g·mol−1
3D model (JSmol)
  • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
  • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
  • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

Interactions

MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Potassium

Drinking alcohol can increase side effects of dexbrompheniramine.

References

  1. ^ Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of International Medical Research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306. S2CID 39205584.


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