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Chemical compound
HU-345
6,6,9-Trimethyl-3-pentyl-1H -benzo[c ]chromene-1,4(6H )-dione
PubChem CID ChemSpider ChEMBL CompTox Dashboard (EPA ) Formula C 21 H 24 O 3 Molar mass 324.420 g·mol−1 3D model (JSmol )
O=C2\C(=C/C(=O)C=3c1c(ccc(c1)C)C(OC2=3)(C)C)CCCCC
InChI=1S/C21H24O3/c1-5-6-7-8-14-12-17(22)18-15-11-13(2)9-10-16(15)21(3,4)24-20(18)19(14)23/h9-12H,5-8H2,1-4H3
Y Key:UFDYTRQMIXJHTH-UHFFFAOYSA-N
Y
(verify)
HU-345 (cannabinol quinone ) is a drug that is able to inhibit aortic ring angiogenesis more potently than its parent compound cannabinol (CBN).[ 1] [ 2] It exhibits no psychoactive effects on the body.
HU-345 can be derived through the oxidative degradation of CBN.[ 3]
See also
References
^ Kogan NM, Blázquez C, Alvarez L, Gallily R, Schlesinger M, Guzmán M, Mechoulam R (July 2006). "A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells". Molecular Pharmacology . 70 (1): 51–9. doi :10.1124/mol.105.021089 . PMID 16571653 . S2CID 4830577 .
^ US patent 0092584 , Mechoulam R, Kogan NM, Rabinowitz R, Schlesinger M, "Therapeutic Use of Quinonoid Derivatives of Cannabinoids", granted 2011-04-21
^ Kogan, Natalya M.; Peters, Maximilian; Mechoulam, Raphael (21 March 2021). "Cannabinoid Quinones—A Review and Novel Observations" . Molecules . 26 (6): 1761. doi :10.3390/molecules26061761 . PMC 8003933 . PMID 33801057 .
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