Bromazine

Bromazine
Clinical data
MedlinePlus	a682065
Routes of; administration	Oral
ATC code	R06AA01 (WHO) ;
Pharmacokinetic data
Bioavailability	High
Protein binding	96%
Metabolism	Mostly hepatic (CYP-mediated), also renal
Elimination half-life	1 to 4 hours
Identifiers
	IUPAC name 2-[(4-Bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine;
CAS Number	1808-12-4 1808-12-4;
PubChem CID	2444;
IUPHAR/BPS	7132;
DrugBank	DB01237 ;
ChemSpider	2350 ;
UNII	202J683U97;
ChEBI	CHEBI:59177 ;
ChEMBL	ChEMBL1201245 ;
CompTox Dashboard (EPA)	DTXSID6022688 ;
ECHA InfoCard	100.003.854
Chemical and physical data
Formula	C17H20BrNO
Molar mass	334.257 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2;
	InChI InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 ; Key:NUNIWXHYABYXKF-UHFFFAOYSA-N ;
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Bromazine (trade names Ambodryl,^[1] Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.^[2] It is a brominated form of diphenhydramine.

References

^ Baker CE (1974). Physicians' Desk Reference (28 ed.). Oradell, NJ 07649: Medical Economics Company. pp. 1076, 1081.{{cite book}}: CS1 maint: location (link)
^ Maclaren WR, Bruff WC, Eisenberg BC, Weiner H, Martin WH (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of Allergy. 13 (3): 307–12. PMID 14377226.

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[1] Baker CE (1974). Physicians' Desk Reference (28 ed.). Oradell, NJ 07649: Medical Economics Company. pp. 1076, 1081.{{cite book}}: CS1 maint: location (link)

[2] Maclaren WR, Bruff WC, Eisenberg BC, Weiner H, Martin WH (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of Allergy. 13 (3): 307–12. PMID 14377226.

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[2]

v t e Antihistamines (R06)
Benzimidazoles (*)	Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine
Diarylmethanes	Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine) Carbinoxamine Chlorphenoxamine Clemastine Diphenhydramine (+naproxen) Diphenylpyraline Doxylamine Ebastine Orphenadrine Diphenylmethanolpiperidines: Fexofenadine Terfenadine Diphenylmethylpiperazines: Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Etodroxizine Hydroxyzine Meclizine Oxatomide Phenylpyridinylpropanamines: Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Pheniramine Others: Acrivastine Bamipine Dimetindene Phenyltoloxamine Pyrrobutamine Quifenadine Triprolidine
Ethylenediamines	Antazoline Chloropyramine Histapyrrodine Mepyramine (pyrilamine) Methapyrilene Phenbenzamine Thenalidine Tripelennamine (pyribenzamine)
Tricyclics	Dibenzocycloheptenes: Antidepressants (e.g., amitriptyline) Azatadine Cyproheptadine Deptropine Desloratadine Ketotifen Loratadine Rupatadine Phenothiazines: Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene
Others	Phenylpiperazines: Antidepressants (e.g., trazodone) Phenbenzamine
For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine