Interleukin 28 receptor, alpha subunit

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Interferon, lambda receptor 1
Protein IL28RA PDB 3OG4.png
Rendering based on PDB 3OG4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IFNLR1 ; CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2
External IDs OMIM607404 MGI2429859 HomoloGene52086 IUPHAR: 1733 GeneCards: IFNLR1 Gene
Species Human Mouse
Entrez 163702 242700
Ensembl ENSG00000185436 ENSMUSG00000062157
UniProt Q8IU57 Q8CGK5
RefSeq (mRNA) NM_170743 NM_174851
RefSeq (protein) NP_734464 NP_777276
Location (UCSC) Chr 1:
24.48 – 24.51 Mb
Chr 4:
135.69 – 135.71 Mb
PubMed search [1] [2]

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]