Interleukin 28 receptor, alpha subunit

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IFNLR1
Protein IL28RA PDB 3OG4.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2, Interleukin 28 receptor, alpha subunit, interferon lambda receptor 1
External IDsMGI: 2429859 HomoloGene: 52086 GeneCards: IFNLR1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IFNLR1
Genomic location for IFNLR1
Band1p36.11Start24,154,157 bp[1]
End24,187,959 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170743
NM_173064
NM_173065

NM_174851

RefSeq (protein)

NP_734464
NP_775087
NP_775088

NP_777276

Location (UCSC)Chr 1: 24.15 – 24.19 MbChr 4: 135.69 – 135.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 28 receptor, alpha subunit is a subunit for the interleukin-28 receptor. IL28RA is its human gene.

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185436 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062157 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".