JWH-184

JWH-184
Legal status
Legal status	UK: Class B;
Identifiers
	IUPAC name 3-[(4-methyl-1-naphthalenyl)methyl]-1-pentyl-1H-indole;
CAS Number	619294-37-0;
ChemSpider	35303439;
Chemical and physical data
Formula	C25H27N
Molar mass	341.49 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCn1cc(c2c1cccc2)Cc3ccc(c4c3cccc4)C;
	InChI InChI=1S/C25H27N/c1-3-4-9-16-26-18-21(24-12-7-8-13-25(24)26)17-20-15-14-19(2)22-10-5-6-11-23(20)22/h5-8,10-15,18H,3-4,9,16-17H2,1-2H3; Key:FSOLXFPDIJJWBM-UHFFFAOYSA-N;

JWH-184 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-122. The binding affinity of JWH-184 for the CB₁ receptor is reported as K_i = 23 ± 6 nM.^[1]

References

^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem. 11 (4): 539–549. doi:10.1016/s0968-0896(02)00451-0. {{cite journal}}: Cite has empty unknown parameter: |month= (help)

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[Huffman_2003-1] Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem. 11 (4): 539–549. doi:10.1016/s0968-0896(02)00451-0. {{cite journal}}: Cite has empty unknown parameter: |month= (help)

[1]

See also

References