Jump to content

List of estrogens available in the United States

Add links
From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Vanished user 0x8cSXE0x6 (talk | contribs) at 10:01, 16 November 2016. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

This is a complete list of estrogens and formulations that are approved by the FDATooltip Food and Drug Administration and available in the United States. Estrogens are used as hormonal contraceptives, in hormone replacement therapy, and in the treatment of gynecological disorders.

Estrogen-only

Oral/sublingual pills

  • Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg, 0.625 mg, 1.25 mg, 2.5 mg
  • Estradiol (Estradiol, Gynodiol, Innofem) – 0.5 mg, 1 mg, 2 mg
  • Estradiol acetate (Femtrace) – 0.45 mg, 0.9 mg, 1.8 mg
  • Estropipate (Estropipate, Ogen .625, Ogen 1.25, Ogen 2.5, Ogen 5, Ortho-Est) – 0.75 mg, 1.5 mg, 3 mg, 6 mg
  • Synthetic conjugated estrogens (Cenestin, Enjuvia)[1] – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg

Atypical (nitrogen mustard alkylating antineoplastic):

Discontinued:

Oral estradiol valerate (except in combination with dienogest as an oral contraceptive) is not available in the U.S. and is used primarily in Europe.[3]

Transdermal patches

  • Estradiol (Alora, Climara, Esclim, Estraderm, Estradiol, Fempatch, Menostar, Minivelle, Vivelle, Vivelle-Dot) – 14 μg/24 hours, 25 μg/24 hours, 37.5 μg/24 hours, 50 μg/24 hours, 60 μg/24 hours, 75 μg/24 hours, 100 μg/24 hours

Transdermal gels

  • Estradiol (Divigel, Elestrin, Estrogel) – 0.06% (0.87 g/activation, 1.25 g/activation), 0.1% (0.25 g/packet, 0.5 g/packet, 1 g/packet)

Transdermal sprays

Topical emulsions

Vaginal tablets

  • Estradiol (Estradiol, Vagifem) – 10 μg (25 μg discontinued)

Vaginal creams

Discontinued:

Vaginal inserts

Vaginal suppositories

Discontinued:

Intramuscular injection

Discontinued:

Combined with progestins

For contraception

⇾ See here instead.

For menopausal symptoms

Oral pills

Discontinued:

Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone, is under development.[4]

Transdermal patches

Combined with androgens

Oral pills

Discontinued:

Injection

Discontinued:

Combined with other drugs

Oral pills

Discontinued:

See also

Notes

  1. ^ Mary C. Brucker; Tekoa L. King (8 September 2015). Pharmacology for Women’s Health. Jones & Bartlett Learning. pp. 640–. ISBN 978-1-284-10811-8. Two types of synthetic estrogen mixtures exist that are primarily used for menopausal hormone therapy: synthetic conjugated estrogens and esterified estrogens. The synthetic conjugated estrogen mixtures are derived from yam or soy plants and contain several types of estrogen. Both synthetic conjugated estrogen products available in the United States (Cenestin with 9 estrogens and Enjuvia with 10 estrogens) contain the primary estrogens in CEE, but the products are not considered equivalent to Premarin.
  2. ^ a b c d e William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 981, 1286, 1833, 2214, 2266. ISBN 978-0-8155-1856-3.
  3. ^ Joseph S. Sanfilippo (January 1998). Primary Care in Obstetrics and Gynecology: A Handbook for Clinicians. Springer Science & Business Media. pp. 227–. ISBN 978-0-387-94739-6.
  4. ^ Pickar JH, Bon C, Amadio JM, Mirkin S, Bernick B (2015). "Pharmacokinetics of the first combination 17β-estradiol/progesterone capsule in clinical development for menopausal hormone therapy". Menopause. 22 (12): 1308–16. doi:10.1097/GME.0000000000000467. PMC 4666011. PMID 25944519.

References


Retrieved from "https://en.wikipedia.org/w/index.php?title=List_of_estrogens_available_in_the_United_States&oldid=749823836"