Odilorhabdins are a class of natural antibacterial agents produced by the bacterium Xenorhabdus nematophila. Odilorhabdins act against both Gram-positive and Gram-negative pathogens, and were shown to eliminate infections in mouse models.
Mechanism of action
Odilorhabdins interfere with the pathogen's protein synthesis and are ribosome-targeting. They bind to the small ribosomal subunit at a site not exploited by previous antibiotics and induce miscoding and premature stop codon bypass. Odilorhabdins were shown to act particularly against carbapenem-resistant Enterobacteriaceae family of bacteria, having potential to kill pathogens with antimicrobial resistance.
The discovery of odilorhabdins was announced in 2013 and formally described in 2018 by the researchers of the University of Illinois at Chicago and Nosopharm. To identify the antibiotic, the Nosopharm researchers tested 80 cultured bacterial strains for antimicrobial properties and then isolated the active compounds.
- Lucile Pantel et al. (5 April 2018). "Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site". Cell. doi:10.1016/j.molcel.2018.03.001.
- Cyndi Root (5 September 2014). "Nosopharm Seeks Partner To Develop Novel, Resistance-Combatting Antibacterial". Bioprocess Online. Retrieved 7 April 2018.
- "A new class of antibiotics to combat drug resistance". Science Daily. 6 April 2018. Retrieved 7 April 2018.