RU-24,969

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RU-24,969
RU-24969 structure.png
Systematic (IUPAC) name
5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
Clinical data
Legal status ?
Identifiers
CAS number 107008-28-6 YesY
ATC code ?
PubChem CID 108029
Chemical data
Formula C14H16N2O 
Mol. mass 228.289 g/mol
 YesY (what is this?)  (verify)

RU-24,969 is a drug and research chemical widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

See also[edit]

References[edit]

  1. ^ Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA. (1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.". Eur J Pharmacol. 112 (3): 363–370. doi:10.1016/0014-2999(85)90782-4. PMID 3160596. 
  2. ^ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience 18 (23): 10078–89. PMID 9822762.