Tropanserin

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Tropanserin
Tropanserin.svg
Clinical data
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C17H23NO2
Molar mass 273.370 g/mol
3D model (JSmol)

Tropanserin (INN; MDL-72,422) is a drug which acts as a potent and selective 5-HT3 receptor antagonist.[1] It was investigated in clinical trials for the treatment of migraine in the 1980s but was never marketed.[2]

Synthesis[edit]

Tropanserin can be prepared by the reaction of tropine with 3,5-dimethylbenzoyl chloride.

Tropanserin synthesis[3]

See also[edit]

References[edit]

  1. ^ Frank D. King; Brian John Jones; Gareth J. Sanger (22 October 1993). 5-Hydroxytryptamine-3 Receptor Antagonists. CRC Press. p. 244. ISBN 978-0-8493-5463-2. Retrieved 6 May 2012. 
  2. ^ Denis M. Bailey (1 August 1987). Annual Reports in Medicinal Chemistry. Academic Press. p. 44. ISBN 978-0-12-040522-0. Retrieved 6 May 2012. 
  3. ^ J. R. Fozard and M. W. Gittos, U.S. Patent 4,563,465 (1986) via Chem. Abstr., 105:54,608j(1986)