From Wikipedia, the free encyclopedia
Jump to: navigation, search
Systematic (IUPAC) name
[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3,5-dimethylbenzoate
CAS Number 85181-40-4
85181-38-0 (HCl)
ATC code None
PubChem CID 68600
ChemSpider 19969918
Chemical data
Formula C17H23NO2
Molar mass 273.370 g/mol

Tropanserin (INN; MDL-72,422) is a drug which acts as a potent and selective 5-HT3 receptor antagonist.[1] It was investigated in clinical trials for the treatment of migraine in the 1980s but was never marketed.[2]


Tropanserin can be prepared by the reaction of tropine with 3,5-dimethylbenzoyl chloride.

Tropanserin synthesis[3]

See also[edit]


  1. ^ Frank D. King; Brian John Jones; Gareth J. Sanger (22 October 1993). 5-Hydroxytryptamine-3 Receptor Antagonists. CRC Press. p. 244. ISBN 978-0-8493-5463-2. Retrieved 6 May 2012. 
  2. ^ Denis M. Bailey (1 August 1987). Annual Reports in Medicinal Chemistry. Academic Press. p. 44. ISBN 978-0-12-040522-0. Retrieved 6 May 2012. 
  3. ^ J. R. Fozard and M. W. Gittos, U.S. Patent 4,563,465 (1986) via Chem. Abstr., 105:54,608j(1986)