5-HT1D receptor

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5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Symbols HTR1D ; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs OMIM182133 MGI96276 HomoloGene20240 IUPHAR: 3 ChEMBL: 1983 GeneCards: HTR1D Gene
RNA expression pattern
PBB GE HTR1D 207368 at tn.png
More reference expression data
Species Human Mouse
Entrez 3352 15552
Ensembl ENSG00000179546 ENSMUSG00000070687
UniProt P28221 Q61224
RefSeq (mRNA) NM_000864 NM_001285482
RefSeq (protein) NP_000855 NP_001272411
Location (UCSC) Chr 1:
23.19 – 23.19 Mb
Chr 4:
136.42 – 136.44 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.[1] 5-HT1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.



  • 5-(Nonyloxy)tryptamine,[2]
  • sumatriptan (vasoconstrictor in migraine)
  • 5-Carboxamidotryptamine (5-CT)
  • 5-(t-Butyl)-N-methyltryptamine[3]
  • CP-135,807
  • CP-286,601
  • PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
  • PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
  • GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
  • L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
  • L-772,405


See also[edit]


  1. ^ "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D". 
  2. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1Dβ serotonin receptor agonist". Journal of Medicinal Chemistry 37 (18): 2828–2830. doi:10.1021/jm00044a001. PMID 8071931. 
  3. ^ Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE (1999). "N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist". Journal of Medicinal Chemistry 42 (3): 526–531. doi:10.1021/jm9805945. PMID 9986723. 

External links[edit]

  • "5-HT1D". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.