UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1Areceptorsilent antagonist. It is structurally related to 8-OH-DPAT. UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.
^ abBjörk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.". J Pharmacol Exp Ther. 258 (1): 58–65. PMID1830099.
^Darmani, N. A.; Reeves, S. L. (1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID8870031.