Tolazamide
Appearance
(Redirected from Tolinase)
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Trade names | Tolinase |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682482 |
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Routes of administration | Oral |
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Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | metabolized in the liver to active metabolites |
Elimination half-life | 7 hours |
Excretion | Renal (85%) and fecal (7%) |
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ECHA InfoCard | 100.013.262 |
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Formula | C14H21N3O3S |
Molar mass | 311.40 g·mol−1 |
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Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Tolazamide_synthesis.png/600px-Tolazamide_synthesis.png)
para-Toluenesulfonamide is converted to its carbamate with ethyl chloroformate in the presence of a base. Heating that intermediate with 1-amino-azepane leads to the displacement of the ethoxy group and the formation of tolazemide:[1]
Azepane proper would lead to [13078-23-4].
References
[edit]External links
[edit]- "Tolazamide". Medline Plus. U.S. National Library of Medicine.