|Systematic (IUPAC) name|
|1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester|
|Mol. mass||358.43 g/mol|
QUPIC (PB-22 or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013. The structure of QUPIC appears to utilise an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. QUPIC represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogues, or the amide of SDB-001 and its analogues. No information regarding the in vitro or in vivo activity of QUPIC has been published, and only anecdotal reports are known of its pharmacology in humans or other animals.
PB-22 is an analog of JWH-018 which differs by having 8-hydroxyquinoline replacing the naphthalene group of JWH-018. The physiological and toxicological properties of this compound are not known. PB-22 is now found in many herbal incense and potpourri products.
A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
Legal in New Zealand sold within as Legal Highs, dosage amount per 2.5gram pack is 107mg
- Uchiyama, N.; Matsuda, S.; Kawamura, M.; Kikura-Hanajiri, R.; Goda, Y. (2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. doi:10.1007/s11419-013-0182-9.
- Southern Association of Forensic Scientists, http://forendex.southernforensic.org/index.php/detail/index/1232
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