LY-293284: Difference between revisions

LY-293284
Identifiers
	IUPAC name (4R)-6-acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz[c,d]indole;
CAS Number	141318-62-9;
PubChem CID	132345;
CompTox Dashboard (EPA)	DTXSID70161692 ;
Chemical and physical data
Formula	C19H26N2O
Molar mass	298.423 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN(CCC)[C@H]1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1;
	(verify)

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 19:31, 10 September 2011

LY-293,284 is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT_1A receptor full agonist. It was derived through structural simplification of the ergoline based hallucinogen LSD,^[1] but is far more selective for 5-HT_1A with over 1000x selectivity over other serotonin receptor subtypes and other targets.^[2] It has anxiogenic effects in animal studies.^[3]

References

^ Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (1998). "Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity". Journal of Medicinal Chemistry. 41 (12): 2134–45. doi:10.1021/jm980076u. PMID 9622555. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (1994). "Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity". The Journal of Pharmacology and Experimental Therapeutics. 270 (3): 1270–81. PMID 7523657. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
^ Cao BJ, Rodgers RJ (1998). "Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice". Psychopharmacology. 139 (3): 185–94. PMID 9784072. {{cite journal}}: Unknown parameter |month= ignored (help)

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[pmid9622555-1] Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (1998). "Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity". Journal of Medicinal Chemistry. 41 (12): 2134–45. doi:10.1021/jm980076u. PMID 9622555. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[pmid7523657-2] Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (1994). "Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity". The Journal of Pharmacology and Experimental Therapeutics. 270 (3): 1270–81. PMID 7523657. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

[pmid9784072-3] Cao BJ, Rodgers RJ (1998). "Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice". Psychopharmacology. 139 (3): 185–94. PMID 9784072. {{cite journal}}: Unknown parameter |month= ignored (help)

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{Drugbox| verifiedrevid = 407858691
+{{Drugbox| verifiedrevid = 424753524
 |
 |IUPAC_name = (4R)-6-acetyl-4-(di-''n''-propylamino)-1,3,4,5-tetrahydrobenz[c,d]indole
@@ Line 8: / Line 8: @@
 | ATC_suffix=
 | PubChem= 132345
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
 | DrugBank=
 | C=19 | H=26 | N=2 | O=1