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Bromazine

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Bromazine
Clinical data
MedlinePlusa682065
Routes of
administration
Oral
ATC code
Pharmacokinetic data
BioavailabilityHigh
Protein binding96%
MetabolismMostly hepatic (CYP-mediated), also renal
Elimination half-life1 to 4 hours
Identifiers
  • 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.003.854 Edit this at Wikidata
Chemical and physical data
FormulaC17H20BrNO
Molar mass334.251 g/mol g·mol−1
3D model (JSmol)
  • Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
  • InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 checkY
  • Key:NUNIWXHYABYXKF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.[1] It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References

  1. ^ MacLaren, W. R.; Bruff, W. C.; Eisenberg, B. C.; Weiner, H.; Martin, W. H. (1955). "A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of Allergy. 13 (3): 307–312. PMID 14377226.