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Elongation factor 1-delta is a protein that in humans is encoded by the EEF1Dgene.[5]
Function
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.[6]
^Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID11829477.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
^Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
^Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID12773547.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity". The Journal of Biological Chemistry. 266 (19): 12574–80. PMID2061327.
van Damme HT, Amons R, Karssies R, Timmers CJ, Janssen GM, Möller W (Aug 1990). "Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta". Biochimica et Biophysica Acta. 1050 (1–3): 241–7. doi:10.1016/0167-4781(90)90174-z. PMID2207149.
Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. PMID2556394.
Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID3169261.
Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R (Aug 1994). "Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes". The Journal of Biological Chemistry. 269 (31): 20201–7. PMID8051108.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Bec G, Kerjan P, Waller JP (Jan 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. PMID8294461.
Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science. 109 (5): 1113–7. PMID8743958.
Chang YW, Traugh JA (Nov 1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry. 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID9353277.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry. 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID9407120.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Xiao H, Neuveut C, Benkirane M, Jeang KT (Mar 1998). "Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation". Biochemical and Biophysical Research Communications. 244 (2): 384–9. doi:10.1006/bbrc.1998.8274. PMID9514931.
Kolettas E, Lymboura M, Khazaie K, Luqmani Y (1998). "Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells". Anticancer Research. 18 (1A): 385–92. PMID9568107.
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. Journal International Du Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID9610721.
Chacko G, Ling Q, Hajjar KA (Jul 1998). "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta". The Journal of Biological Chemistry. 273 (31): 19840–6. doi:10.1074/jbc.273.31.19840. PMID9677419.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry. 191 (1–2): 181–6. doi:10.1023/A:1006802125856. PMID10094407.
Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID11829477.
Lei YX, Chen JK, Wu ZL (2002). "Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential". Teratogenesis, Carcinogenesis, and Mutagenesis. 22 (5): 377–83. doi:10.1002/tcm.10034. PMID12210501.