EMD-386088

EMD-386088
Clinical data
ATC code	none;
Identifiers
	IUPAC name 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole;
CAS Number	54635-62-0 ;
PubChem CID	10131112;
CompTox Dashboard (EPA)	DTXSID30436055 ;
Chemical and physical data
Formula	C14H14ClN2
Molar mass	245.727 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2cc1c(cc2)nc(C)c1C=3CCNCC=3;
	(verify)

EMD-386088 is an indole derivative which is used in scientific research. It acts as a potent and selective 5-HT₆ receptor agonist, with a K_i of 1 nM, a significantly higher affinity than older 5-HT₆ agonists such as EMDT, although it possesses moderate affinity for the 5-HT₃ receptor as well.^[1]

References

^ Mattsson, C; Sonesson, C; Sandahl, A; Greiner, HE; Gassen, M; Plaschke, J; Leibrock, J; Böttcher, H (2005). "2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists". Bioorganic & Medicinal Chemistry Letters. 15 (19): 4230–4. doi:10.1016/j.bmcl.2005.06.067. PMID 16055331.

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