HU-243

HU-243
Identifiers
	IUPAC name (6aR,8S,9S,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-8,9-ditritio-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-1-ol;
CAS Number	140835-18-3 ;
PubChem CID	3081854;
IUPHAR/BPS	735;
CompTox Dashboard (EPA)	DTXSID701101448 ;
Chemical and physical data
Formula	C25H40O3
Molar mass	388.30 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(O1)(C)[C@H]2[C@@H](C[C@H](CO)CC2)C3=C1C=C(C(C)(C)CCCCCC)C=C3O;

HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a potent agonist at both the CB₁ and CB₂ receptors, with a binding affinity of 0.041 nM at the CB₁ receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.^[1]

References

^ Stern, E.; Lambert, D. M. (2007). "Medicinal Chemistry Endeavors around the Phytocannabinoids". Chemistry & Biodiversity. 4 (8): 1707–1728. doi:10.1002/cbdv.200790149. PMID 17712816.

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[1] Stern, E.; Lambert, D. M. (2007). "Medicinal Chemistry Endeavors around the Phytocannabinoids". Chemistry & Biodiversity. 4 (8): 1707–1728. doi:10.1002/cbdv.200790149. PMID 17712816.

[1]

See also

References