ORG-37684

ORG-37684
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name (3S)-3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]pyrrolidine;
CAS Number	213007-95-5;
PubChem CID	9794656;
IUPHAR/BPS	171;
ChemSpider	7970423;
CompTox Dashboard (EPA)	DTXSID201029269 ;
Chemical and physical data
Formula	C14H19NO2
Molar mass	233.305 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1c(OC)ccc2c1CCC2)[C@H]3CCNC3;
	InChI InChI=1S/C14H19NO2/c1-16-13-6-5-10-3-2-4-12(10)14(13)17-11-7-8-15-9-11/h5-6,11,15H,2-4,7-9H2,1H3/t11-/m0/s1; Key:QDJAYXYEXHVXJV-NSHDSACASA-N;
	(verify)

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT₂ receptor family, with highest affinity at 5-HT_2C and lowest at 5-HT_2B subtypes.^[1]^[2] It has anorectic effects in animal studies and has been researched as a potential weight loss drug for use in humans.^[3]

References

^ Adams, D.; Duncton, M. (2001). "EFFICIENT SYNTHESIS OF THE 5-HT2C RECEPTOR AGONIST, ORG 37684". Synthetic Communications. 31 (13): 2029–2036. doi:10.1081/SCC-100104420.
^ Knight, AR; Misra, A; Quirk, K; Benwell, K; Revell, D; Kennett, G; Bickerdike, M (2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–123. doi:10.1007/s00210-004-0951-4. PMID 15322733.
^ Schreiber, R; De Vry, J (April 2002). "Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat". Prog. Neuropsychopharmacol. Biol. Psychiatry. 26 (3): 441–9. doi:10.1016/s0278-5846(01)00284-6. PMID 11999893.

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