JWH-018
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| Legal status |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.163.574 |
| Chemical and physical data | |
| Formula | C24H23NO |
| Molar mass | 341.45 g/mol g·mol−1 |
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with some selectivity for CB2.[1][2][3] It produces effects in animals very similar to those of THC itself, but with a longer duration of action, and is currently being researched as a potential analgesic to be administered by transdermal patch.[4].
On December 15th 2008, it was claimed without confirmation by a German pharmaceutical company THC Pharm, that JWH-018 was found as one of the active components in at least three versions of the herbal blend Spice, which has been sold as an incense, in a number of countries around the world since 2002. [5][6][7]
Legal status
Canada
Health Canada has stated an opinion that JWH-018 falls under item 1 of schedule 2 of the Controlled Drugs and Substances Act, as a "similar synthetic preparation" to cannabis, even though it has no chemical relation to cannabis derived cannabinoids.[8]
Austria
The Austrian Ministry of Health announced on 18th December 2008 that Spice would be controlled under Paragraph 78 of their drug law on the grounds that it contains an active substance which affects the functions of the body, and the legality of JWH-018 is under review.
Germany
JWH-018 is illegal in Germany since 22nd of January 2009.[9]
Lithuania
JWH-018 is illegal in Lithuania since 27th of May 2009
Sweden
JWH-018 is illegal in Sweden since 30th of July 2009. The bill was accepted on 30th July 2009 and will be in effect on 15th September 2009.[10]
Worldwide
In most other countries JWH-018 is legal and available online.
See also
References
- ^ Aung, M. M. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–140. doi:10.1016/S0376-8716(99)00152-0.
{{cite journal}}: Cite has empty unknown parameter:|month=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ US patent 6900236, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2005-05-31
- ^ US patent 7241799, Alexandros Makriyannis, Hongfeng Deng, "Cannabimimetic indole derivatives", issued 2007-07-10
- ^ Transdermal Delivery of Cannabinoids. WO/2007/001891
- ^ Gefährlicher Kick mit Spice (German)
- ^ Erstmals Bestandteile der Modedroge „Spice“ nachgewiesen (German)
- ^ Spice enthält chemischen Wirkstoff (German)
- ^ Correspondence from Health Canada
- ^ BGBl I Nr. 3 vom 21.01.2009, 22. BtMÄndV vom 19. Januar 2009, S. 49–50.
- ^ [1](Swedish)
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