Metabolism of this compound has been recently assessed, revealing diclazepam has an approximate elimination half-life of 42 h and undergoes N-demethylation to delorazepam, as expected, which can be detected in urine for 6 days following administration of the parent compound. Other metabolites detected were lorazepam and lormetazepam which were detectable in urine for 19 and 11 days, respectively, indicating hydroxylation by P450 enzymes occurring concurrently with N-demethylation.
^ ab"Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics". Drug Testing and Analysis6 (7-8): 757–763. July–August 2014. doi:10.1002/dta.1628. PMID24604775.