ETS2

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V-ets avian erythroblastosis virus E26 oncogene homolog 2
Protein ETS2 PDB 1k78.png
PDB rendering based on 1k78.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ETS2 ; ETS2IT1
External IDs OMIM164740 MGI95456 HomoloGene3838 GeneCards: ETS2 Gene
RNA expression pattern
PBB GE ETS2 201329 s at tn.png
PBB GE ETS2 201328 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2114 23872
Ensembl ENSG00000157557 ENSMUSG00000022895
UniProt P15036 P15037
RefSeq (mRNA) NM_001256295 NM_011809
RefSeq (protein) NP_001243224 NP_035939
Location (UCSC) Chr 21:
40.18 – 40.2 Mb
Chr 16:
95.7 – 95.72 Mb
PubMed search [1] [2]

Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene.[1][2] The protein encoded by this gene belongs to the ETS family of transcription factors.[1]

Interactions[edit]

ETS2 has been shown to interact with ZMYND11,[3] ERG,[4] Cyclin-dependent kinase 10[5] and C-jun.[4] myb,[6]

References[edit]

  1. ^ a b Dwyer J, Li H, Xu D, Liu JP (Nov 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Ann N Y Acad Sci 1114 (1): 36–47. doi:10.1196/annals.1396.022. PMID 17986575. 
  2. ^ "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)". 
  3. ^ Wei, Guo; Schaffner Alicia Erbe; Baker Kimberly M; Mansky Kim C; Ostrowski Michael C (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Res. (Greece) 23 (3A): 2173–8. ISSN 0250-7005. PMID 12894593. 
  4. ^ a b Basuyaux, J P; Ferreira E; Stéhelin D; Butticè G (Oct 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". J. Biol. Chem. (UNITED STATES) 272 (42): 26188–95. doi:10.1074/jbc.272.42.26188. ISSN 0021-9258. PMID 9334186. 
  5. ^ Kasten, M; Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene (England) 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. ISSN 0950-9232. PMID 11313931. 
  6. ^ Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (Feb 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proc Natl Acad Sci U S A 89 (4): 1291–5. doi:10.1073/pnas.89.4.1291. PMC 48435. PMID 1741383. 


Further reading[edit]

External links[edit]