RVD-Hpα: Difference between revisions
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added information about human α1-hemoglobin, alpha 1 to protein box and indicated that RVD-Hpα polypeptide is a fragment of the parent protein |
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{{protein |
{{protein |
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| Name = RVD-Hpα |
| Name = RVD-Hpα fragment of hemoglobin, alpha 1 |
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| caption = Amino acid residues 92-104 (RVDPVNFKLLSH) in the human sequence |
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| caption = |
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| image = |
| image = |
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| width = |
| width = |
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| HGNCid = |
| HGNCid = 4823 |
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| Symbol = |
| Symbol = [[Hemoglobin, alpha 1|HBA1]] |
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| AltSymbols = |
| AltSymbols = |
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| EntrezGene = |
| EntrezGene = 3039 |
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| OMIM = |
| OMIM = 141800 |
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| RefSeq = |
| RefSeq = NM_000558 |
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| UniProt = |
| UniProt = P69905 |
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| PDB = |
| PDB = |
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| ECnumber = |
| ECnumber = |
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| Chromosome = |
| Chromosome = 16 |
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| Arm = |
| Arm = p |
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| Band = |
| Band = 13.3 |
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| LocusSupplementaryData = |
| LocusSupplementaryData = |
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}} |
}} |
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Revision as of 07:51, 22 March 2010
| RVD-Hpα fragment of hemoglobin, alpha 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | HBA1 | ||||||
| NCBI gene | 3039 | ||||||
| HGNC | 4823 | ||||||
| OMIM | 141800 | ||||||
| RefSeq | NM_000558 | ||||||
| UniProt | P69905 | ||||||
| Other data | |||||||
| Locus | Chr. 16 p13.3 | ||||||
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RVD-Hpα is an endogenous neuropeptide found in human and mammalian brain, which acts as a selective agonist for the CB1 cannabinoid receptor. It is a 12-amino acid polypeptide having the amino acid sequence Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His and is an N-terminal extended form of hemopressin, a 9-AA polypeptide derived from the α1 subunit of hemoglobin which has previously been shown to act as a CB1 inverse agonist.[1] The shorter 11-AA polypeptide VD-Hpα was found to be an agonist at both CB1 and CB2 receptors. All three polypeptides have been isolated from various mammalian species, with RVD-Hpα being one of the more abundant neuropeptides expressed in mouse brain, and these neuropeptides represent a new avenue for cannabinoid research distinct from the previously known endogenous lipid-derived cannabinoid agonists such as anandamide.[2]
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18077343, please use {{cite journal}} with
|pmid=18077343instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19380512, please use {{cite journal}} with
|pmid=19380512instead.