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AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoidagonist.[1] It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2]
^Martin, Billy R.; Compton, David R.; Semus, Simon F.; Lin, Sonyuan; Marciniak, Gilbert; Grzybowska, Jolanta; Charalambous, Avgui; Makriyannis, Alexandros (1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC". Pharmacology Biochemistry and Behavior. 46 (2): 295–301. doi:10.1016/0091-3057(93)90356-X. ISSN0091-3057.
^Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology, Biochemistry and Behaviour. 1991 Nov;40(3):509-12. PMID 1666915