CID16020046

CID16020046
Identifiers
	IUPAC name 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid;
CAS Number	834903-43-4;
PubChem CID	16020046;
IUPHAR/BPS	6577;
ChemSpider	12543007;
ECHA InfoCard	100.233.214
Chemical and physical data
Formula	C25H19N3O4
Molar mass	425.435 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc5ccc(c3n[nH]c4C(=O)N(c1ccc(C(=O)O)cc1)C(c2cccc(O)c2)c34)cc5;
	InChI InChI=1S/C25H19N3O4/c1-14-5-7-15(8-6-14)21-20-22(27-26-21)24(30)28(18-11-9-16(10-12-18)25(31)32)23(20)17-3-2-4-19(29)13-17/h2-13,23,29H,1H3,(H,26,27)(H,31,32); Key:VGUQVYZXABOXCX-UHFFFAOYSA-N;

CID-16020046 is a compound which acts as an inverse agonist at the former orphan receptor GPR55, and may be the first selective inverse agonist characterised for this receptor. It was found to block a number of GPR55 mediated responses such as wound healing and activation of immune system T-cells and B-cells, as well as showing inverse agonist activity in the absence of GPR55 agonist stimulation. However while it was found to have good selectivity over the related CB₁ and CB₂ cannabinoid receptors as well as a number of other targets, CID-16020046 has not yet been tested against another related receptor GPR18, so its selectivity for GPR55 over this target has not been established.^[1]

References

^ Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A (July 2013). "A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function". The Journal of Pharmacology and Experimental Therapeutics. 346 (1): 54–66. doi:10.1124/jpet.113.204180. PMID 23639801.

[pmid23639801-1] Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A (July 2013). "A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function". The Journal of Pharmacology and Experimental Therapeutics. 346 (1): 54–66. doi:10.1124/jpet.113.204180. PMID 23639801.

[1]

See also

References