Crotylsarin
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This is an old revision of this page, as edited by Citation bot (talk | contribs) at 16:07, 12 October 2018 (Add: pmid. You can use this bot yourself. Report bugs here. | Zakblade2000). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 16:07, 12 October 2018 by Citation bot (talk | contribs) (Add: pmid. You can use this bot yourself. Report bugs here. | Zakblade2000)
Names | |
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IUPAC name
(2E)-2-Buten-1-yl methylphosphonofluoridate
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Other names
CRS
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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Properties | |
C5H10FO2P | |
Molar mass | 152.105 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Crotylsarin (CRS) is an extremely toxic organophosphate nerve agent of the G-series.[1] Like other nerve agents, CRS irreversibly inhibits the acetylcholinesterase. However, since the inhibited enzyme ages so rapidly, the inhibited enzyme can't be reactivated by oxime reactivators.[2][3]
See also
References
- ^ Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst (27 June 2016). "Toxicology of organophosphorus compounds in view of an increasing terrorist threat". Archives of Toxicology. 90 (9): 2131–2145. doi:10.1007/s00204-016-1772-1. PMID 27349770.
- ^ Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. (January 1991). "Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat". Toxicology. 69 (3): 331–344. doi:10.1016/0300-483x(91)90191-3.
- ^ Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. (21 November 2012). "The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors". Archives of Toxicology. 87 (4): 711–719. doi:10.1007/s00204-012-0977-1. PMID 23179755.
Animal toxins | |
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Bacterial | |
Cyanotoxins | |
Plant toxins | |
Mycotoxins | |
Pesticides | |
Nerve agents | |
Bicyclic phosphates | |
Cholinergic neurotoxins | |
Other |
Enzyme (modulators) |
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Transporter (modulators) |
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