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PSNCBAM-1
1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea
CAS Number PubChem CID CompTox Dashboard (EPA ) Formula C 22 H 21 Cl N 4 O Molar mass 392.89 g·mol−1 3D model (JSmol )
Clc1ccc(NC(=O)Nc2cccc(c2)c3cccc(n3)N4CCCC4)cc1
InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
Key:HDAYFSFWIPRJSO-UHFFFAOYSA-N
PSNCBAM-1 is a negative allosteric modulator of the cannabinoid CB1 receptor .[1] [2]
See also
References
^ {{cite journal | title=Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1) | vauthors=German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y | journal=Journal of Medicinal Chemistry | date=September 2014 | volume=57 | issue=18 | pages=7758–7769 | doi=10.1021/jm501042u | pmid=25162172 | PMC=4175001}}
^ Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P (November 2007). "PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats" . British Journal of Pharmacology . 152 (5): 805–814. doi :10.1038/sj.bjp.0707347 . PMC 2190018 . PMID 17592509 .
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A-796,260
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Others: 2-PG (directly potentiates activity of 2-AG at CB1 receptor)
ARN-272 (FAAH-like anandamide transporter inhibitor)