Ribosomal protein S6
| ribosomal protein S6 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RPS6 | ||||||
| NCBI gene | 6194 | ||||||
| HGNC | 10429 | ||||||
| OMIM | 180460 | ||||||
| RefSeq | NM_001010 | ||||||
| UniProt | P62753 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p21 | ||||||
| |||||||
Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.[1]
Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function.
References
- ^ Magnuson B, Ekim B, Fingar DC (January 2012). "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks". The Biochemical Journal. 441 (1): 1–21. doi:10.1042/BJ20110892. PMID 22168436.
External links
- Ribosomal+Protein+S6 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)