CCR8 (gene)

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Chemokine (C-C motif) receptor 8
Identifiers
Symbols CCR8 ; CC-CKR-8; CCR-8; CDw198; CKRL1; CMKBR8; CMKBRL2; CY6; GPRCY6; TER1
External IDs OMIM601834 MGI1201402 HomoloGene21080 IUPHAR: 65 ChEMBL: 4596 GeneCards: CCR8 Gene
RNA expression pattern
PBB GE CCR8 208059 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1237 12776
Ensembl ENSG00000179934 ENSMUSG00000042262
UniProt P51685 P56484
RefSeq (mRNA) NM_005201 NM_007720
RefSeq (protein) NP_005192 NP_031746
Location (UCSC) Chr 3:
39.37 – 39.38 Mb
Chr 9:
120.09 – 120.09 Mb
PubMed search [1] [2]

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.[1] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function[edit]

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.[2] CCL8 also functions as a CCR8 agonist.[3]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.[1]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8". 
  2. ^ Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW et al. (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332. 
  3. ^ Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B et al. (2011). "Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells". Nat. Immunol. 12 (2): 167–77. doi:10.1038/ni.1984. PMC 3863381. PMID 21217759. 

External links[edit]

  • "Chemokine Receptors: CCR8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

  • Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339. 
  • Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT et al. (1996). "Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues". J. Immunol. 157 (7): 2759–63. PMID 8816377. 
  • Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020. 
  • Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M (1996). "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor". Eur. J. Immunol. 26 (12): 3021–8. doi:10.1002/eji.1830261230. PMID 8977299. 
  • Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C et al. (1997). "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309". J. Exp. Med. 186 (1): 165–70. doi:10.1084/jem.186.1.165. PMC 2198957. PMID 9207005. 
  • Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859. 
  • Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S et al. (1998). "The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains". J. Biol. Chem. 273 (1): 386–91. doi:10.1074/jbc.273.1.386. PMID 9417093. 
  • Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G (1998). "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3". J. Immunol. 160 (4): 1975–81. PMID 9469461. 
  • Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H (1998). "Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection". Biochem. Biophys. Res. Commun. 243 (2): 497–502. doi:10.1006/bbrc.1998.8130. PMID 9480837. 
  • Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M et al. (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068. 
  • Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlazzi CT, Sinigaglia F et al. (1998). "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". J. Immunol. 161 (2): 547–51. PMID 9670926. 
  • Efremov R, Truong MJ, Darcissac EC, Zeng J, Grau O, Vergoten G et al. (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function". Eur. J. Biochem. 263 (3): 746–56. doi:10.1046/j.1432-1327.1999.00553.x. PMID 10469138. 
  • Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW et al. (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332. 
  • Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB (2000). "CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor". J. Virol. 74 (15): 6946–52. doi:10.1128/JVI.74.15.6946-6952.2000. PMC 112211. PMID 10888633. 
  • Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood 96 (3): 840–5. PMID 10910894. 
  • Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K et al. (2000). "Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny". Stem Cells 18 (5): 374–81. doi:10.1634/stemcells.18-5-374. PMID 11007922. 
  • Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D et al. (2002). "Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives". AIDS Res. Hum. Retroviruses 18 (1): 1–11. doi:10.1089/088922202753394664. PMID 11804551. 
  • Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V et al. (2002). "Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes". J. Exp. Med. 196 (3): 379–87. doi:10.1084/jem.20020110. PMC 2193942. PMID 12163566. 
  • Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC et al. (2003). "The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway". J. Leukoc. Biol. 73 (1): 201–7. doi:10.1189/jlb.0302105. PMID 12525579. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.