60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21gene.[5][6][7]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
Clinical relevance
Mutations in the RPL21 gene result in Hypotrichosis simplex of the scalp.[8]
^Zhou C; Zang D; Jin Y; et al. (March 2011). "Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex". Human Mutation. 32 (7): 710–4. doi:10.1002/humu.21503. PMID21412954. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Further reading
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID8722009.
Kato S; Sekine S; Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID7821789. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Albertsen HM; Smith SA; Mazoyer S; et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID7951316. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID11401437.
Odintsova TI; Müller EC; Ivanov AV; et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID12962325. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)