Cannabipiperidiethanone

Cannabipiperidiethanone
Identifiers
	IUPAC name 2-(2-methoxyphenyl)-1-[1-([1-methylpiperidin-2-yl]methyl)indol-3-yl]ethanone;
CAS Number	1345970-43-5;
ChemSpider	27330303;
CompTox Dashboard (EPA)	DTXSID90705471 ;
Chemical and physical data
Formula	C24H28N2O2
Molar mass	376.490 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc2ccccc2CC(=O)c(c4c1cccc4)cn1CC3CCCCN3C;
	InChI InChI=1S/C24H28N2O2/c1-25-14-8-7-10-19(25)16-26-17-21(20-11-4-5-12-22(20)26)23(27)15-18-9-3-6-13-24(18)28-2/h3-6,9,11-13,17,19H,7-8,10,14-16H2,1-2H3; Key:AJSBNWAHEDVQJT-UHFFFAOYSA-N;

Cannabipiperidiethanone, (CPE, or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole), is a synthetic cannabinoid that has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122 and JWH-081. Its binding affinity was measured at the CB₁ and CB₂ receptors and it was found to have an IC₅₀ of 591nM at CB₁ and 968nM at CB₂, making it 2.3x and 9.4x weaker than JWH-250 at these two targets respectively.^[1]

References

^ Uchiyama N, Kikura-Hanajiri R, Goda Y (2011). "Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB₁ and CB₂ receptors". Chemical & Pharmaceutical Bulletin. 59 (9): 1203–5. doi:10.1248/cpb.59.1203. PMID 21881274.

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[pmid21881274-1] Uchiyama N, Kikura-Hanajiri R, Goda Y (2011). "Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB₁ and CB₂ receptors". Chemical & Pharmaceutical Bulletin. 59 (9): 1203–5. doi:10.1248/cpb.59.1203. PMID 21881274.

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See also

References