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Interferon, kappa
Symbols IFNK ; IFNT1; INFE1
External IDs OMIM615326 MGI2683287 HomoloGene36384 GeneCards: IFNK Gene
Species Human Mouse
Entrez 56832 387510
Ensembl ENSG00000147896 ENSMUSG00000042993
UniProt Q9P0W0 Q7TSL0
RefSeq (mRNA) NM_020124 NM_199157
RefSeq (protein) NP_064509 NP_954608
Location (UCSC) Chr 9:
27.52 – 27.53 Mb
Chr 4:
35.15 – 35.15 Mb
PubMed search [1] [2]

Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[1][2][3]


IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[1]


  1. ^ a b "Entrez Gene: interferon". 
  2. ^ LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA (October 2001). "Interferon-kappa, a novel type I interferon expressed in human keratinocytes". J. Biol. Chem. 276 (43): 39765–71. doi:10.1074/jbc.M102502200. PMID 11514542. 
  3. ^ Nardelli B, Zaritskaya L, Semenuk M, Cho YH, LaFleur DW, Shah D, Ullrich S, Girolomoni G, Albanesi C, Moore PA (November 2002). "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system". J. Immunol. 169 (9): 4822–30. doi:10.4049/jimmunol.169.9.4822. PMID 12391192. 

3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.