Lymphotoxin beta

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For the snowboard company, see LTB (company). For lateral torsional buckling, see Buckling#Lateral-torsional_buckling.
Lymphotoxin beta (TNF superfamily, member 3)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LTB ; TNFC; TNFSF3; p33
External IDs OMIM600978 MGI104796 HomoloGene1752 GeneCards: LTB Gene
RNA expression pattern
PBB GE LTB 207339 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4050 16994
Ensembl ENSG00000204487 ENSMUSG00000024399
UniProt Q06643 P41155
RefSeq (mRNA) NM_002341 NM_008518
RefSeq (protein) NP_002332 NP_032544
Location (UCSC) Chr 6:
31.58 – 31.58 Mb
Chr 17:
35.19 – 35.2 Mb
PubMed search [1] [2]

Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene.[1][2][3]


Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]


LTB has been shown to interact with Lymphotoxin alpha.[4][5][6]


  1. ^ Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF (April 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell 72 (6): 847–56. doi:10.1016/0092-8674(93)90574-A. PMID 7916655. 
  2. ^ Browning JL, Androlewicz MJ, Ware CF (September 1991). "Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma". J Immunol 147 (4): 1230–7. PMID 1714477. 
  3. ^ a b "Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)". 
  4. ^ Williams-Abbott, L; Walter B N; Cheung T C; Goh C R; Porter A G; Ware C F (August 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". J. Biol. Chem. (UNITED STATES) 272 (31): 19451–6. doi:10.1074/jbc.272.31.19451. ISSN 0021-9258. PMID 9235946. 
  5. ^ Browning, J L; Sizing I D, Lawton P, Bourdon P R, Rennert P D, Majeau G R, Ambrose C M, Hession C, Miatkowski K, Griffiths D A, Ngam-ek A, Meier W, Benjamin C D, Hochman P S (October 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". J. Immunol. (UNITED STATES) 159 (7): 3288–98. ISSN 0022-1767. PMID 9317127. 
  6. ^ Browning, J L; Dougas I; Ngam-ek A; Bourdon P R; Ehrenfels B N; Miatkowski K; Zafari M; Yampaglia A M; Lawton P; Meier W (January 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". J. Immunol. (UNITED STATES) 154 (1): 33–46. ISSN 0022-1767. PMID 7995952. 

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