60S ribosomal protein L21

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases RPL21, HYPT12, L21, ribosomal protein L21
External IDs MGI: 1278340 HomoloGene: 128048 GeneCards: RPL21
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 13: 27.25 – 27.26 Mb Chr 5: 146.83 – 146.84 Mb
PubMed search [1] [2]
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60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

Clinical relevance[edit]

Mutations in the RPL21 gene result in Hypotrichosis simplex of the scalp.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nakamichi NN, Kao FT, Wasmuth J, Roufa DJ (Jul 1986). "Ribosomal protein gene sequences map to human chromosomes 5, 8, and 17". Somat Cell Mol Genet. 12 (3): 225–36. doi:10.1007/BF01570781. PMID 3459254. 
  4. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601. 
  5. ^ a b "Entrez Gene: RPL21 ribosomal protein L21". 
  6. ^ Zhou C, Zang D, Jin Y, et al. (March 2011). "Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex". Human Mutation. 32 (7): 710–4. doi:10.1002/humu.21503. PMID 21412954. 

Further reading[edit]