60S ribosomal protein L3

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RPL3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPL3, ASC-1, L3, TARBP-B, ribosomal protein L3
External IDs MGI: 1351605 HomoloGene: 747 GeneCards: RPL3
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for RPL3
Genomic location for RPL3
Band 22q13.1 Start 39,312,882 bp[1]
End 39,320,389 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033853
NM_000967

NM_013762

RefSeq (protein)

NP_000958
NP_001029025

NP_038790

Location (UCSC) Chr 22: 39.31 – 39.32 Mb Chr 22: 80.08 – 80.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.[5][6][7]

Function[edit]

Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100316 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060036 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ou JH, Yen TS, Wang YF, Kam WK, Rutter WJ (Jan 1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res. 15 (21): 8919–34. PMC 306413Freely accessible. PMID 2891103. doi:10.1093/nar/15.21.8919. 
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A Map of 75 Human Ribosomal Protein Genes". Genome Research. 8 (5): 509–523. PMID 9582194. doi:10.1101/gr.8.5.509. 
  7. ^ a b "Entrez Gene: RPL3 ribosomal protein L3". 

Further reading[edit]

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. PMID 8722009. doi:10.1139/o95-101. 
  • Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. PMID 1538749. doi:10.1038/355632a0. 
  • Reddy TR, Suhasini M, Rappaport J, Looney DJ, Kraus G, Wong-Staal F (1995). "Molecular cloning and characterization of a TAR-binding nuclear factor from T cells". AIDS Res. Hum. Retroviruses. 11 (6): 663–9. PMID 7576925. doi:10.1089/aid.1995.11.663. 
  • Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819. doi:10.1016/0378-1119(94)90293-3. 
  • Van Raay TJ, Connors TD, Klinger KW, Landes GM, Burn TC (1997). "A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 37 (2): 172–6. PMID 8921388. doi:10.1006/geno.1996.0538. 
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. PMID 10591208. doi:10.1038/990031. 
  • Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T (2000). "The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs". Biochim. Biophys. Acta. 1490 (3): 225–36. PMID 10684968. doi:10.1016/S0167-4781(99)00237-7. 
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. PMID 11401437. doi:10.1006/geno.2000.6470. 
  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298. doi:10.1016/S0960-9822(01)00650-9. 
  • Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN, Kostka S, Otto A, Wittmann-Liebold B, Karpova GG (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. PMID 12962325. doi:10.1023/A:1025068419698. 
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086. 
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. PMC 545604Freely accessible. PMID 15461802. doi:10.1186/gb-2004-5-10-r84. 
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. PMID 15592455. doi:10.1038/nbt1046. 
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. PMID 15635413. doi:10.1038/nature03207.