60S ribosomal protein L35a

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases RPL35A, DBA5, L35A, ribosomal protein L35a
External IDs MGI: 1928894 HomoloGene: 129020 GeneCards: RPL35A
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 3: 197.95 – 197.96 Mb Chr 16: 33.06 – 33.06 Mb
PubMed search [1] [2]
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60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483. 
  4. ^ Colombo P, Read M, Fried M (Sep 1996). "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics. 32 (1): 148–50. doi:10.1006/geno.1996.0093. PMID 8786106. 
  5. ^ a b "Entrez Gene: RPL35A ribosomal protein L35a". 

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