Clentiazem

Clentiazem
Names
	IUPAC name acetic acid [(2S,3S)-8-chloro-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] ester
Identifiers
CAS Number	111659-76-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	51418 ;
PubChem CID	57026;
UNII	40DK034DRC ;
	InChI InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1 Key: GYKFWCDBQAFCLJ-RTWAWAEBSA-N ; InChI=1/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1 Key: GYKFWCDBQAFCLJ-RTWAWAEBBL;
	SMILES CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC;
Properties
Chemical formula	C22H25ClN2O4S
Molar mass	448.9629
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Clentiazem is a calcium channel blocker.^[1]

It is a chloride derivative of diltiazem.^[2]

References

^ Giasson S, Garceau D, Homsy W, Dumont L (October 1995). "Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs". Cardiovasc Drugs Ther. 9 (5): 685–92. doi:10.1007/BF00878551. PMID 8573551.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Dagenais F, Hollmann C, Buluran J, Cartier R (October 1995). "Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia". Can J Cardiol. 11 (9): 816–22. PMID 7585280.{{cite journal}}: CS1 maint: multiple names: authors list (link)