Lidoflazine

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Lidoflazine
Lidoflazine.png
Systematic (IUPAC) name
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 3416-26-0
ATC code C08EX01
PubChem CID 3926
UNII J4ZHN3HBTE YesY
KEGG D04733 YesY
Chemical data
Formula C30H35F2N3O 
Mol. mass 491.615
Physical data
Melt. point 159–161 °C (318–322 °F)
Solubility in water Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
 YesY (what is this?)  (verify)

Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.

Physical properties[edit]

Solubility at room temperature[edit]

Extracted from [2]

Solvent 0.01

N

0.1

N

 % pH  % pH
Hydrochloric Acid 0.4 3.0 0.7 1.9
Tartaric Acid 0.3 3.1 1.0 2.5
Citric Acid 0.3 3.1 0.5 2.5
Lactic Acid 0.2 3.4 0.7 2.9
Acetic Acid 0.1 3.5 0.4 3.8

References[edit]

  1. ^ Schaper, W.K.A.; Xhonneux, R.; Jageneau, A.H.M.; Janssen, P.A.J. (1966). "The cardiovascular pharmacology of lidoflazine, a long-acting coronary vasodilator". Journal of Pharmacology and Experimental Therapeutics 152 (2): 265–274. PMID 5944369. Retrieved 2009-06-20. 
  2. ^ http://jpet.aspetjournals.org/cgi/content/abstract/152/2/265
  • Schaper WK, Xhonneux R, Jageneau AH., Stimulation of the coronary collateral circulation by lidoflazine (R 7904), Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 November 4;252(1):1-8.