Interleukin 27 receptor, alpha subunit

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Interleukin 27 receptor, alpha
Symbols IL27RA ; CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1
External IDs OMIM605350 MGI1355318 HomoloGene3562 IUPHAR: 2318 GeneCards: IL27RA Gene
RNA expression pattern
PBB GE IL27RA 222062 at tn.png
PBB GE IL27RA 205926 at tn.png
PBB GE IL27RA 217702 at tn.png
More reference expression data
Species Human Mouse
Entrez 9466 50931
Ensembl ENSG00000104998 ENSMUSG00000005465
UniProt Q6UWB1 O70394
RefSeq (mRNA) NM_004843 NM_016671
RefSeq (protein) NP_004834 NP_057880
Location (UCSC) Chr 19:
14.14 – 14.16 Mb
Chr 8:
84.03 – 84.04 Mb
PubMed search [1] [2]

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.[1]


In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.[1]


Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.[2]


  1. ^ a b "Entrez Gene: IL27RA interleukin 27 receptor, alpha". 
  2. ^ Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW et al. (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330. 

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