TNFRSF17

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tumor necrosis factor receptor superfamily, member 17

PDB rendering based on 1oqd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TNFRSF17 ; BCM; BCMA; CD269
External IDs OMIM109545 MGI1343050 HomoloGene920 GeneCards: TNFRSF17 Gene
RNA expression pattern
PBB GE TNFRSF17 206641 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 608 21935
Ensembl ENSG00000048462 ENSMUSG00000022496
UniProt Q02223 O88472
RefSeq (mRNA) NM_001192 NM_011608
RefSeq (protein) NP_001183 NP_035738
Location (UCSC) Chr 16:
12.06 – 12.06 Mb
Chr 16:
11.31 – 11.32 Mb
PubMed search [1] [2]
BCMA TALL-1 binding domain
PDB 1oqd EBI.jpg
crystal structure of stall-1 and bcma
Identifiers
Symbol BCMA-Tall_bind
Pfam PF09257
InterPro IPR015337
SCOP 1oqd
SUPERFAMILY 1oqd

Tumor necrosis factor receptor superfamily member 17 is a protein that in humans is encoded by the TNFRSF17 gene.[1][2][3]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[3]

Interactions[edit]

TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B.[4][5] A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.[4]

References[edit]

  1. ^ Laabi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (November 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma". EMBO J 11 (11): 3897–904. PMC 556899. PMID 1396583. 
  2. ^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (May 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed". Nucleic Acids Res 22 (7): 1147–54. doi:10.1093/nar/22.7.1147. PMC 523635. PMID 8165126. 
  3. ^ a b "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17". 
  4. ^ a b Liu, Yingfang; Hong Xia, Kappler John, Jiang Ling, Zhang Rongguang, Xu Liangguo, Pan Cheol-Ho, Martin Wesley E, Murphy Robert C, Shu Hong-Bing, Dai Shaodong, Zhang Gongyi (May 2003). "Ligand-receptor binding revealed by the TNF family member TALL-1". Nature (England) 423 (6935): 49–56. doi:10.1038/nature01543. ISSN 0028-0836. PMID 12721620. 
  5. ^ Shu, H B; Johnson H (August 2000). "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9156–61. doi:10.1073/pnas.160213497. ISSN 0027-8424. PMC 16838. PMID 10908663. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article incorporates text from the public domain Pfam and InterPro IPR015337